Chemical Composition and Biological Activity of Salicornia fruticosa L. | ||||
| Egyptian Journal of Chemistry | ||||
| Article 9, Volume 63, Issue 5, May 2020, Page 1713-1721 PDF (1.26 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2019.18470.2139 | ||||
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| Authors | ||||
Rasha Abdel Elatif1; Manal Shabana2; lamyaa fawzy2; Ragaa Mansour2; Hanem Awad3; Mahmed sharaf   4
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| 1Phytochemistry and Plant Systematics Department, National Research Centre, El-Dokki, Cairo Egypt. | ||||
| 2Phytochemistry and Plant Systematics, National Research centre | ||||
| 3Regulatory Toxicology Lab, Centre of Excellence. National Research Centre, El-Dokki | ||||
| 4National Research center, DOKKI, Cairo, Egypt. | ||||
| Abstract | ||||
| Abstract Plants have been used as a source of traditional medicine to treat many diseases and conditions for many years. They considered as excellent source of phytochemicals which showed antioxidant and anticancer activities. The aim of the present study is to investigate the chemical composition and to determine the anticancer activity of Salicornia fruticosa (Chenopodiaceae) methanolic extract. S. fruticosa proved to be a source of isorhamnetin and its glycosides and showed anticancer activities. Seven major flavonoids were isolated and identified from the cytotoxic methanolic extract. The isolated compounds were identified, as quercetin 3',4'-dimethyl ether (1), isorhamnetin (2), isorhamnetin 3-O-rhamnoside (3), isorhamnetin 3-O-glucoside (4), isorhamnetin 3-O-rutinoside (5), isorhamnetin 3-O-neohesperidoside (6), isorhamnetin 3-O-rhamnosyl(1-2)arabinoside (7), by chromatographic analysis, chemical and spectroscopic tools (acid hydrolysis, UV, 1H and 13C NMR). Compounds 1 and 3-7 were isolated for the first time from the plant under investigation. The evaluation of cytotoxic activity of the methanolic extract against HCT-116, HepG2, A549 and MCF-7 human cancer cells, by MTT assay, revealed the higher potency of S. Fruticosa extract with IC50 [2.6. 10.9, 37.9, 5.4 (g/ml)] respectively, comparable to that of doxorubicin. The obtained results suggested that the investigated plant could be used for future development of naturally occurring anticancer agent. Subclinical and clinical trials on polar fractions of S. fruticosa are mandatory to pave the way for its use in treatment of cancer diseases (HCT-116, HepG2, A549 and MCF-7). | ||||
| Keywords | ||||
| Keywords Salicornia fruticosa; Chenopodiaceae; flavonoids. isorhamnetin derivatives; Anticancer activity | ||||
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