Pharmacokinetic Studies Of Ceftiofur (Ceftiprima In Calves) | ||||
| Journal of Current Veterinary Research | ||||
| Article 10, Volume 1, Issue 2, November 2019, Page 95-104 PDF (431.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jcvr.2019.57065 | ||||
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| Authors | ||||
Mohamed talaat  1; Taha Attia2; Mohamed El-Hewaity3
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| 1department of pharmacology faculty of veterinary medecine university of sadat city | ||||
| 2Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Egypt | ||||
| 3Department of Pharmacology, Faculty of Veterinary Medicine, Menoufia University, Egypt. | ||||
| Abstract | ||||
| ABSTRACT: The kinetic profile of ceftiofur in calves was studied after single intramuscular and intravenous administrations at a dose of 2.2 mg ceftiofur/kg b.wt. Serum concentrations of ceftiofur were determined by using high performance liquid chromatography (HPLC). Following compartmental analysis, a two-compartment open model best described the concentration-time data of ceftiofur after i.m. and i.v. administration. After intramuscular administration, the drug reached its maximum serum concentrations (Cmax) of 6.51 ± 0.123 μg/ml at maximum time (Tmax) of 2.49 ± 0.073 h,absorption half-life (t1/2ab) was 0.57 ± 0.035 h and (AUC0-t) was 100. 8 ± 0.69 μg/ml.h.Following a single intravenous injection, the drug was detected till 24 hours, distribution half-life (t1/2α) was 0.11 ± 0.01 h, elimination half-life (t1/2β) was of 11.07 ± 0.12 h and clearance (CL) was 0.013 ± 0.005 (L/kg/h), volume of distribution at steady state (Vdss) was 0.16 ± 0.004 (L/kg) and bioavailability was 64.66±0.39%. | ||||
| Keywords | ||||
| ceftiofur – Bioavailability –HPLC – calves | ||||
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