Ultrastructural and immunophenotype distribution of Telocytes in female genital tract of adult albino rats | ||||
| The Egyptian Journal of Anatomy | ||||
| Article 5, Volume 40, Issue 1, January 2017, Page 75-93 PDF (3.31 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejana.2017.5714 | ||||
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| Authors | ||||
| Hala Soliman1; Manal Abd El-Haleem2; Ghalia Attia3; Maha Al Desoki4 | ||||
| 1Professor of Histology [M.D],Department of Anatomy, Faculty of Medicine, Taibah University, Al Madina Al Monawarrah, KSA; Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||||
| 2Associate Professor of Histology [M.D], Department of Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||||
| 3Associate Professor of Histology [M.D], Department of Anatomy, Faculty of Medicine, Taibah University, Al Madina Al Monawarrah, KSA; Department of Histology and Cell Biology, Faculty of Medicine, Mansoura University, Al Mansoura, Egypt. | ||||
| 4Assistant Professor of Anatomy [M.D], Department of Anatomy, Faculty of Medicine, Taibah University, Al Madina Al Monawarrah, KSA; Department of Anatomy, Faculty of Medicine,Al Menia, Egypt. | ||||
| Abstract | ||||
| Background: Few information was given about Telocyte (TC) which was recently discovered in the last few years. Aim of the work: This study was designed to give full histological, immunohistochemichal and ultrastructural preview on TCs distribution in the female genital tract. Material and method: After vaginal smear examination, thirty rats in diestrus phase were subjected for this study. Uterine, fallopian tube and vaginal specimens were taken and processed for both light and electron microscopic examination. Results: TCs showed weak positive ER-α and marked immunoexpression of PR-A and CD34 in the endometrial stroma and around the glands, in stratum vascular and outer longitudinal smooth muscle layers of the uterus, serosa of the fallopian tube and in the lamina propria in addition to the connective tissue under vaginal epithelium and around and within the bundles of the vagina. Ultrastructurally, the uterus, fallopian tube and vagina showed triangular or stellate- shaped TCs that contained elongated nucleus occupying the whole cell body with thin band of marginal heterochromatin and prominent nucleolus and had one or more telopodes (TPs) with dichotomous pattern of branching. TPs had thin podomere and thick podom. Podom contains many mitochondria, rough endoplasmic reticulum (RER), many caveolae and pinchedout vesicles. TCs had either homocellular junction between them or heterocellular junction with adjacent smooth muscle cells. TCs were surrounded by collagen fibers. Conclusion:TCs are new type of cells with special ultrastructure and immunophenotype characters that are detected in the female genital tract ,therefore further studies on their distribution in the female genital tract during different stages of estrus cycle, and trying to correlate between their distribution and their role in controlling infertility or myometrial contraction during pregnancy should be considered. | ||||
| Keywords | ||||
| Fallopian tube; Immunohistochemistry; telocytes; Ultrastructure; Uterus; Vagina | ||||
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