Protective Effect of Spirulina Against Irradiation Induced Liver Injury in Adult Albino Rat Rats | ||||
| The Egyptian Journal of Anatomy | ||||
| Article 6, Volume 40, Issue 1, January 2017, Page 94-106 PDF (12.42 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejana.2017.5715 | ||||
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| Authors | ||||
| Rania Salah El Din1; Rasha Abd-Elgawad2 | ||||
| 1Associate Professor of Anatomy and Embryology, Faculty of Medicine, Ain Shams University,Egypt | ||||
| 2Lecturer of Anatomy and Embryology, Faculty of Medicine, Ain Shams University, Egypt | ||||
| Abstract | ||||
| Background and Objective: Spirulina is a nutritional supplement that has a variety of pharmacological properties, such as antioxidant and anti-inflammatory effects. This study aimed to investigate the protective effect of Spirulina against liver tissue injury induced by gamma irradiation. Materials and Methods: Thirty two adult male albino rats were divided into 4 groups each of which included 8 rats: (1) control group, (2) irradiation group: exposed to gamma irradiation in a dose of 8 Gy for 15 min, (3) Spirulina low dose treated (SPL) group which received Spirulina 300 mg/kg b.w. by gavage once/day for 3 weeks prior to irradiation and (4) Spirulina high dose treated (SPH) group which received Spirulina 1000 mg/kg b.w. by gavage once/day for 3 weeks before irradiation. Blood samples were collected to determine levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA) and plasma total proteins, in addition to liver tissue from all groups to be examined histologically by light microscope and transmission electron microscope. Results: The obtained results showed that plasma levels of ALT and AST were significantly reduced in rats treated with low dose of Spirulina prior to irradiation when compared to irradiation group together with significant rise of plasma total proteins and histological improvement of liver tissue, however, Spirulina high dose treated group did not show any signs of improvement compared to irradiation group. It could be concluded that low dose Spirulina treatment has a hepatoprotective effect against irradiation, whereas high dose treatment may have a hepatotoxic effect that needs further investigations. | ||||
| Keywords | ||||
| Spirulina; Hepatoprotective; Irradiation | ||||
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