EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS
Hassan, S., EL Sabbagh, A., El Mahalawy, A. (2019). EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS. EKB Journal Management System, 44(2), 120-124. doi: 10.21608/adjalexu.2019.57375
Sameh M. Hassan; Ahmed M. EL Sabbagh; Ahmed S. El Mahalawy. "EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS". EKB Journal Management System, 44, 2, 2019, 120-124. doi: 10.21608/adjalexu.2019.57375
Hassan, S., EL Sabbagh, A., El Mahalawy, A. (2019). 'EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS', EKB Journal Management System, 44(2), pp. 120-124. doi: 10.21608/adjalexu.2019.57375
Hassan, S., EL Sabbagh, A., El Mahalawy, A. EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS. EKB Journal Management System, 2019; 44(2): 120-124. doi: 10.21608/adjalexu.2019.57375

EVALUATION OF AMNIOTIC MEMBRANE IN TREATMENT OF CERVICO-FACIAL KELOID SCARS

Alexandria Dental Journal
Article 20, Volume 44, Issue 2, August 2019, Page 120-124  XML PDF (441.44 K)
Document Type: Original Article
DOI: 10.21608/adjalexu.2019.57375
View on SCiNiTO View on SCiNiTO
Authors
Sameh M. Hassan; Ahmed M. EL Sabbagh; Ahmed S. El Mahalawy
Abstract
INTRODUCTION: Amniotic membrane is the innermost layer of the placenta consisting of a thick basement membrane and an avascular stromal matrix. It can be used as a graft and as a dressing to promote healing. OBJECTIVES: Evaluation of the use of amniotic membrane in cases with keloids in Cervico-facial region. MATERIALS AND METHODS: A clinical study was conducted on 10 patients with keloids. The sample was selected conveniently to fulfill a list of inclusion and exclusion criteria. Then the selected participants have undergone surgical excision of the scar with placement of amniotic membrane under the skin at the excised site and wound closure by primary intention and amniotic membrane was used as a dressing as well. Follow up and clinical evaluation was performed over a period of 3 months using Vancouver Score Scale. RESULTS: Follow‐up data collected 3months after the final treatment revealed decreases in the mean score for the following lesion features. Pigmentation from 1.3 to 1.1; Vascularity from 1.3 to 1.2; Pliability from 3.7 to 2.7 and height from 1.6 to 1.1. CONCLUSIONS: The present study showed that the combination of surgical excision and Amniotic membrane placement can be used as a new alternative in treatment of keloid scars.
Keywords
Amniotic membrane allograft; keloid scars; Wound healing; Vancouver Score Scale
References
  1. Kanitakis J. Anatomy, histology and immunohistochemistry of normal human skin. Eur J Dermatol. 2002;12:390-9;quiz 400-1.
  2. Velnar T, Bailey T, Smrkolj V. The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res. 2009;37:1528-42.
  3. Van Zuijlen PP, Ruurda JJ, van Veen HA, van Marle J, van Trier AJ, Groenevelt F, et al. Collagen morphology in human skin and scar tissue: no adaptations in response to mechanical loading at joints. Burns. 2003;29:423-31
  4. Sommerlad BC, Creasey JM. The stretched scar: A clinical and histological study: BC Sommerland and JM Creasey. Br J Plast Surg. 1979;31:26–28.
  5. Butler PD, Longaker MT, Yang GP. Current Progress in Keloid Research and Treatment. J Am Coll Surg. 2008r;206:731-41.
  6. Tuan TL, Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today. 1998;4:19- 24.
  7. Alenghat FJ, Ingber DE. Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE. 2002;2002:e6.
  8. Suarez E, Syed F, Alonso-Rasgado T, Mandal P, Bayat A.. Up-regulation of tension- related proteins in keloids: Knockdown of hsp27, α2β1-integrin, and pai-2 shows convincing reduction of extracellular matrix production. Plast Reconstr Surg. 2013;131:158e-73e.
  9. Wong VW, Rustad KC, Akaishi S, Sorkin M, Glotzbach JP, Januszyk M, et al. Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med. 2011;18:148-52.
  10. Poetschke J, Gauglitz GG, Current options for the treatment of pathological scarring, J Dtsch Dermatol Ges 2016;14:467-77.
  11. Fearmonti R, Bond J, Erdmann D, Levinson H. A Review of Scar Scales and Scar Measuring Devices. Eplasty. 2010;10:e43.
  12. Berman B, Perez OA, Konda S, Kohut BE, Viera MH, Delgado S, et al. A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management. Dermatol Surg. 2007;33:1291-303.
  13. Verhaegen PD, van Zuijlen PP, Pennings NM, van Marle J, Niessen FB, van der Horst CM, et al. Differences in collagen architecture between keloid, hypertrophic scar, normotrophic scar, and normal skin: An objective histopathological analysis. Wound Repair Regen. 2009;17:649-56.
  14. Burd A, Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg 2005;116:150e-7e.
  15. Mohammadi AA, Eskandari S, Johari HG, Rajabnejad A. Using Amniotic Membrane as a Novel Method to Reduce Post-burn Hypertrophic Scar Formation: A Prospective Follow-up Study. J Cutan Aesthet Surg. 2017;10:13-7.
  16. Cho SB, Lee JH, Lee SH, Lee SJ, Bang D, Oh SH. Efficacy and safety of 1064-nm Q-switched Nd:YAG laser with low fluence for keloids and hypertrophic scars. Eur Acad Dermatol Venereol. 2010;24:1070-4.
  17. Mustoe TA. Evolution of silicone therapy and mechanism of action in scar management. Aesthetic Plast Surg. 2008;32:82-92.
  18. Choi Y-H, Kim K-M, Kim H-O, Jang Y-C, Kwak I-S. Clinical and Histological Correlation in Post-Burn Hypertrophic Scar for Pain and Itching Sensation. Ann Dermatol. 2013;25:428-33.
Statistics
Article View: 244
PDF Download: 854