Detection of oxidative stress induced by ciprofloxacin in imatuer rat | ||||
Research Journal of Applied Biotechnology | ||||
Article 6, Volume 4, Issue 1, June 2018, Page 77-81 PDF (610.14 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/rjab.2018.57521 | ||||
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Authors | ||||
Amal A. AbdEl-Aziz1; Yahya Naguib2; Wafaa A. Zahran3; Hoda Mahrous 4; Hany Khalil1; Saadiya A. El-Nahas5 | ||||
1Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt | ||||
2Clinical Physiology Department, Faculty of Medicine, Menofiya University, Menofiyam Egypt | ||||
3Microbiology and immunology Department, faculty of medicine, Menofiya University, Menofiya, Egypt | ||||
4Industerial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt | ||||
51Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt | ||||
Abstract | ||||
Fluoroquinolones are a group of antibiotics broadly used because of their wide spectrum activity against both Gram-negative and Gram positive bacteria. It is well tolerated in patients but their uses have been associated with numerous adverse effects, including adverse central nervous system (CNS) effects and juvenile joint toxicity due to oxidative stress. This study designed to detect the oxidative stress caused by administration of ciprofloxacin alone and in concert with glutathione. Ciprofloxacin (400 mg/kg body weight) administered to rats alone or with glutathione (100 mg/kg) body weight for7 days injection via intra peritoneal route to detect effects on glutathione peroxidase and glutathione reductase as oxidative stress enzymes markers. The data obtained demonstrated presence of the two enzymes which supplies further evidence that fluoroquinolones at therapeutic doses promote oxidative stress and the crucial role of glutathione in ptotection against ciprofloxacin side effects on bone. | ||||
Keywords | ||||
ciprofloxacin; Oxidative Stress; side effects; antioxidants | ||||
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