Effect of glutathione on antimicrobial activity of levofloxacin

AbdEl-Aziz, Amal A.; Zahran, Wafaa A.; Mahrous, Hoda; Khalil, Hany; El-Khayat, Amira H.; El-Nahas, Saadiya A.

doi:10.21608/rjab.2018.57524

	Effect of glutathione on antimicrobial activity of levofloxacin
Research Journal of Applied Biotechnology
Article 7, Volume 4, Issue 1, June 2018, Page 82-86 PDF (662.45 K)
Document Type: Original Article
DOI: 10.21608/rjab.2018.57524
View on SCiNiTO
Authors
Amal A. AbdEl-Aziz¹; Wafaa A. Zahran²; Hoda Mahrous ³; Hany Khalil¹; Amira H. El-Khayat²; Saadiya A. El-Nahas¹
¹Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt
²Microbiology and Immunology Department, faculty of Medicine, Menofiya University, Menofiya, Egypt
³Industerial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt
Abstract
Overuse of antibiotics has become the major factor for the emergence anddissemination of multi-drug resistant strains of several groups of microorganisms andthis lead to search for agents that may be asolution,Fluoroquinolones are a group of antibiotics widelyused because of their broad spectrum activity against both Gram-positive and Gram-negative bacteria. In this study We report the effect of glutathione on the antibacterial action of levofloxacin on E-coli and S. aureus aslevofloxacin is an important and commonly used members of the fluoroquinolonesantibiotics.Itinhibit DNA topoisomerase II and DNA topoisomerase IV activities, eventually leading tobacterial cell death. In addition, an increase of reactive oxygen species in the bacterial cells in response to levofloxacin has been shown.
Keywords
Fluoroquinolones; side effects; microbial activity and antioxidants


Statistics Article View: 190 PDF Download: 298