The Effect of Intramuscular Administration of Dexamethasone Alone or in Combination with Hyoscine Butylbromide in Shortening the duration of Induced Labor in Primigravidas | ||||
| The Medical Journal of Cairo University | ||||
| Article 27, Volume 86, September, September 2018, Page 2335-2340 PDF (490.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.57534 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| OMNEYA HELAL, M.D.; MOUTAZ EL-SHERBINI, M.D.; SHERIF S. ZAKI, M.D. | ||||
| The Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt | ||||
| Abstract | ||||
| Abstract Background: Induction of labour is common in clinical practice and is usually troublesome in primigravidas. Obesta-tricians are always in search of the best method of induction to ensure the best maternal and fetal outcome. Aim of Study: To evaluate the effect of Intramuscular (IM) administration of dexamethasone alone or in combined with Hyoscine Butylbromide (HBB) on the duration of labour induction in primigravidas. Patients and Methods: A randomized controlled study was conducted at the Obstetrics and Gynecology casualty department at Kasr Al-Ainy Hospital (Cairo University, Egypt) in the period from November 2015 to April 2016. 150 primi-gravidas with a singleton living healthy fetus who underwent Induction of Labour (IOL) participated in the study. They were randomly allocated into 3 groups: Group A where 50 women received IM dexamethasone (8mg) 6 hours prior to induction then IM 2ml saline at the onset of the active phase, Group B where 50 women received IM dexamethasone (8mg) 6 hours prior to induction then IM HBB (40mg) at the onset of the active phase and Group C (control) where 50 women received two IM saline injections (2mL) 6 hours prior to induction and at the onset of the active phase. IOL was done using 2.5mIU/min intravenous drip of oxytocin (in 500mL lactated Ringer's solution), increasing the dose by 2.5mIU/ml every 20 minutes until labour started. Amniotomy was done at a cervical dilatation of ³6cm, if spontaneous rupture of the membranes had not spontaneously occurred. All participants were monitored by a partogram and continuous CTG through-out labor. Results: Both groups A and B showed significant short-ening of the duration of the latent phase (3.4±0.6 and 3.6±0.7 vs 4.5±0.6hrs), the duration of the active phase (3.7±0.7 and 3.7±0.6 vs. 4.8±0.7hrs), the duration of the 2nd stage (21.6± 5.3 and 21.9±7.2 vs. 30.0±5.3 minutes) as well as the duration of the 3rd stage (6.3±1.7 and 7.5±1.9 vs. 10.0±2.8 minutes) respectively when compared to the control group (p-value <0.001 for all). No statistical significant differences were noticed in neonatal Apgar score at 1 and 5 minutes between the three groups. Conclusions: Intramuscular injection of dexamethasone alone or in addition to hyoscine butylbromide was found to shorten the duration of induced labour in primigravidas, with no observed maternal or neonatal complications. | ||||
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