Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma
B, A., Zakaria, N., Mohamed, D., Omar, A., Seif, A. (2019). Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma. EKB Journal Management System, 36(1), 358-366. doi: 10.21608/jsrs.2019.57635
Ahmed B. B; N.M Zakaria; D. A. Mohamed; A. R Omar; A. M Seif. "Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma". EKB Journal Management System, 36, 1, 2019, 358-366. doi: 10.21608/jsrs.2019.57635
B, A., Zakaria, N., Mohamed, D., Omar, A., Seif, A. (2019). 'Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma', EKB Journal Management System, 36(1), pp. 358-366. doi: 10.21608/jsrs.2019.57635
B, A., Zakaria, N., Mohamed, D., Omar, A., Seif, A. Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma. EKB Journal Management System, 2019; 36(1): 358-366. doi: 10.21608/jsrs.2019.57635

Matrix Metalloproteinase-13 (MMP-13): A proposed Tumor Marker in Breast Carcinoma

Journal of Scientific Research in Science
Article 22, Volume 36, Issue 1, April 2019, Page 358-366  XML PDF (601.42 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2019.57635
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Authors
Ahmed B. B1; N.M Zakaria2; D. A. Mohamed3; A. R Omar4; A. M Seif* 4
1,Microbiology Department, Faculty of Science, Ain Shams University.
2, Clinical Pathology Department, Faculty of Medicine, Ain Shams University.
3Clinical Pathology Department, Faculty of Medicine, Ain Shams University. Abstract:
4Microbiology Department, Faculty of Science, Ain Shams University.
Abstract
Breast cancer is estimated to account for 31% new onset female cancers. Matrix metalloproteinases (MMPs) are extracellular zinc-dependent endopeptidases involved in the degradation and remodeling of extracellular matrix in physiological and pathological processes. In this study, we aimed to evaluate the use of matrix metalloproteinase-13 (MMP-13) as a potential tumor marker in breast cancer and we also aimed to investigate the role of infection as a cause of carcinogenesis by estimating the incidence of anti-cytomegalovirus IgG antibodies in breast cancer patients.
Subjects and Methods:
Serum CA15.3, anti-CMV IgG and MMP-13 were measured in 50 breast cancer female patients, 20 female patients with fibroadenoma of breast and 20 healthy age-matched female volunteers.
Results:
MMP-13 levels showed no significant difference between breast cancer patients and controls; on the other hand MMP-13 levels were significantly higher in fibroadenoma patients compared to controls. CA15.3 levels were significantly higher in breast cancer cases compared to both fibroadenoma and healthy controls.
Conclusion:
The results of this study show that MMP-13 level is highest among control group, while fibroadenoma group had the lowest MMP-13 level. CA15.3 is still the most useful serum tumor marker in patients with breast cancer.
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