Studying the behavioral changes in schizophrenic rats induced by chronic exposure to ketamine | ||||
| Journal of Scientific Research in Science | ||||
| Article 25, Volume 36, Issue 1, April 2019, Page 403-411 PDF (429.19 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jsrs.2019.57771 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mona El Sayed* 1; Samiha M. Abd El Dayem1; Asmaa M. Zaazaa1; Hanaa H. Ahmed2 | ||||
| 1Department of Zoology -Girl's college for Arts, Science and Education. Ain Shams University. | ||||
| 2Department of Hormones, National Research Centre, Cairo, Egypt. | ||||
| Abstract | ||||
| Schizophrenia is a chronic and highly complex psychiatric disorder characterised by cognitive dysfunctions, negative and positive symptoms. The major challenge in schizophrenia research is lack of suitable animal models that mimic the core behavioural aspects and symptoms of this devastating psychiatric disorder. In this study, we used classical and atypical antipsychotic drugs to examine the predictive validity of ketamine-enhanced immobility in forced swim test (FST) as a possible animal model for the negative symptoms of schizophrenia. Repeated administration of a subanaesthetic dose of ketamine (0.1 mg / kg b.wt.) for 60 days enhanced the duration of immobility in FST 24 h after the final injection. Suggesting that the effects of ketamine on the duration of immobility in this study was neither due to motor dysfunction nor peripheral neuromuscular blockade. Our results suggest that repeated treatment with subanaesthetic doses of ketamine enhance the duration of immobility in FST, which might be a useful animal model for the negative symptoms (particularly the depressive features) of schizophrenia. | ||||
| Keywords | ||||
| Key words: Schizophrenia; Ketamine; forced swim test; Rats | ||||
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