EFFECT OF CALCITONIN INTRA MUSCULAR INJECTION ON BONE FORMATION AROUND TITANIUM DENTAL IMPLANTS IN DOGS (A HISTOLOGICAL STUDY) | ||||
| Alexandria Dental Journal | ||||
| Article 7, Volume 42, Issue 1, April 2017, Page 40-46 PDF (878.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2017.57855 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mohamed L. Gabr* 1; Ahmed R. Kotb2; RihamM. El Dibany3 | ||||
| 1Dentist, Faculty of Dentistry, Alexandria University, Egypt | ||||
| 2Professor of Oral and Maxillofacial surgery, Faculty of Dentistry, Alexandria University, Egypt | ||||
| 3Professor of Oral and Maxillofacial surgery, Faculty of Dentistry, Alexandria University, Egypt. | ||||
| Abstract | ||||
| INTRODUCTION: Calcitonin is a major hormone secreted by thyroid gland responsible for bone formation and decrease of blood calcium level. It is a mixture of amino acids plus a modifying agent. It has been proved that the synthetic salmon calcitonin enhanced bone growth in depth as well as in width that is why they used it as a treatment for bone diseases and fractures. OBJECTIVES: This study was done to evaluate histologically the effect of intra muscular (IM) calcitonin administration on bone healing around titanium dental implants. MATERIALS AND METHODS: Twelve adult’s Mongrel dogs received one implant in the maxilla in the edentulous space distal to the canine. Six dogs were randomly selected as the test group then they received a single daily dose of calcitonin 50 IU administered IM, for 28 successive days. And six dogs served as control group and no medications were injected. The animals were sacrificed 4, 8, and 12 weeks after surgery. RESULTS: Through microscopical examination of specimens showed an apparent trend toward increased new bone formation in the osteotomy site in the calcitonin-treated group compared with the controls in fourth and eighth week intervals. While in twelfth interval there was a non-significant difference could be noticed between control and study groups concerning new bone formation which gave firm attachment between host bone tissue and the used implant. CONCLUSIONS: This study demonstrated that using short, small dose of salmon calcitonin by daily intramuscular injection for 28 days enhanced bone mineral density when compared with the bone density without injection of this material. | ||||
| Keywords | ||||
| Calcitonin; dogs; bone formation; Dental implants | ||||
| References | ||||
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