Effect of Exercise on Metabolic Disorders Associated with Obesity | ||||
| The Medical Journal of Cairo University | ||||
| Article 44, Volume 86, September, September 2018, Page 2493-2499 PDF (429.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.57879 | ||||
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| Authors | ||||
| ASMAA S.Y. MOHAMED, M.Sc.; RANIA N. ABD EL-LATIF, M.D.; SOHA S. ZAKARIA, M.D.; THANAA F. EL-SHEIKH, M.D. | ||||
| The Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| Abstract | ||||
| Abstract Background: The epidemic of obesity has contributed to the rapid rise in comorbid conditions such as cardiovascular disease, type 2 diabetes mellitus and hypertension. Aim of Study: The aim of this study was to determine the effect of exercise on metabolic disorders and mitochondrial dysfunction associated with obesity. Material and Methods: The study was conducted on 60 male albino rats divided randomly into four equal groups: Group I: Control non-trained group; Group II: Obese non-trained group; Group II: Control trained group and Group IV: Obese trained group. Obesity was induced by hydrating rats with 70% fructose solution for 5 weeks. Following induction of obesity and after 8 consecutive weeks of swimming exercise, citrate synthase enzyme activity was measured by a kinetic spectrophotometric assay. Plasma insulin level was measured by ELISA and insulin resistance was assessed using (HOMA-IR index), while plasma levels of glucose, triglycerides and total cholesterol were determined by colorimetric assay. Results: The levels of glucose, total cholesterol, triglyc-erides and insulin resistance were significantly increased in obese non-trained group but significantly decreased in obese trained group compared to control groups. Also citrate synthase activity was significantly increased in obese trained group compared to obese non-trained group. Conclusion: Endurance exercise results in improvement of obesity and glucose homeostasis. | ||||
| Keywords | ||||
| Obesity – Metabolic syndrome – Mitochondrial dysfunction – Citrate synthase enzyme – HOMA-IR index | ||||
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