STUDY OF THE EFFECT OF THE COMBINATION OF PLATELET-RICH FIBRIN (PRF) AND ALLOGENOUS BONE GRAFT AROUND IMMEDIATE IMPLANTS | ||||
| Alexandria Dental Journal | ||||
| Article 1, Volume 42, Issue 2, December 2017, Page 127-134 PDF (1007.91 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2017.57915 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Shaimaa A. Zaki* 1; Sherif S. Mohamed2; Ahmed M. Hommos3; Adham A. El Ashwah4 | ||||
| 1B.D.S. Faculty of Dentistry Alexandria University | ||||
| 2Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry Alexandria University | ||||
| 3Professor of Periodontology, Oral Medicine, Diagnosis and Radiology, Faculty of Dentistry Alexandria University | ||||
| 4Assistant Professor of Oral and Maxillofacial Surgery, Faculty of Dentistry Alexandria University | ||||
| Abstract | ||||
| INTRODUCTION: Following the immediate implant placement, there is a gap called jumping space which increases the risk of implant failure. OBJECTIVES: The aim of the study was to evaluate the clinical and radiographic efficiency of platelet-rich fibrin membrane (PRF) combined with bone graft surrounding immediate implants in fresh extraction sockets. MATERIALS AND METHODS: A clinical and radiographic study was carried out on ten fresh extraction sockets with age range from 20 to 50 years. Sockets were occupied by immediate endosseous implant and grafted with allogenous bone graft and PRF. After placement all implants were evaluated clinically after 6 months (modified sulcus bleeding index, probing pocket depth and degree of mobility) and radiographically to evaluate marginal bone loss. RESULTS: There was less pain, edema, bleeding and probing depth in the study group than in the control group but the difference among them was not statistically significant (P > 0.05). There was significantly more bone density and less marginal bone loss in the study group than in the control group on the sixth postoperative month (P < 0.05). CONCLUSIONS: It is clear that PRF is biocompatible and can improve both soft tissue healing and bone regeneration after immediate implant placement. | ||||
| Keywords | ||||
| Immediate implant; PRF; bone graft | ||||
| References | ||||
|
1. Albrektsson T, Sennerby L, Wennerberg A. State of the art of oral implants. Periodontal 2000. 2008; 47: 15-26.
2. Araújo MG, Lindhe J. Ridge alterations following tooth extraction with and without flap elevation: an experimental study in the dog. Clin Oral Implants Res. 2009; 20: 545-9.
3. Tan WL, Wong TLT, Wong MCM, Lang NP. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans. Clin Oral Implants Res. 2012; 23: 1-21.
4. VittoriniOrgeas G, Clementini M, De Risi V, de Sanctis M. Surgical techniques for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Implants. 2013; 28: 1049-61.
5. Schropp L, Wenzel A, Kostopoulos L, Karring T. Bone healing and soft tissue contour changes following singletooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodont Restor Dent. 2003; 23: 313-23.
6. Shulte W, Heimke G. The Tubinger immediate implant. Quintessenz 1976; 27: 17-23.
7. Anneroth G, Hedstrom KG, Kjellman O, Kondell PA, Nordenram A. Endosseus titanium implants in extraction sockets. An experimental study in monkeys. Int J Oral Surg. 1985; 14: 50-4.
8. Covani U, Cornelini R, Calvo JL, Tonelli P, Barone A. Bone remodeling around implants placed in fresh extraction sockets. Int J Periodontics Restorative Dent. 2010; 30: 601- 7.
9. Botticelli D, Berglundh T, Buser D, Lindhe J. The jumping distance revisited: an experimental study in the dog. Clin Oral Implants Res. 2003; 14: 35-42.
10. Santos PL, Gulinelli JL, Telles Cda S, Betoni Júnior W, Okamoto R, Chiacchio Buchignani V, et al. Bone Substitutes for Peri-Implant Defects of Postextraction Implants. Int J Biomater. 2013; 2013: 307136.
11. Schepers S, Barbier P, Ducheyne L. Bioactive glass particles as a filler for bone lesions. J Oral Rehabil. 1991; 18: L439-52.
12. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: e37-44.
13. Gassling VL, Açil Y, Springer IN, Hubert N, Wiltfang J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108: 48-55.
14.Ross R, Glomset J, Kariya B, Harker L. A plateletdependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci USA. 1974; 71: 1207-10.
15. Nevins M, Giannobile WV, McGuire MK, Kao RT, Mellonig JT, Hinrichs JE, et al. Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: Results of a large multicenter randomized controlled trial. J Periodontal. 2005; 76: 2205-15.
16. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 85: 638-46.
17. Choukroun J, Dohan DM, Diss A, Dohan SL, Dohan AJ, Mouhyi J, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: e37-44.
18. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT, Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost. 2004; 91: 4-15.
19. Hiremath H, Saikalyan S, Kulkarni S, Hiremath V. Second generation platelet concentrate (PRF) as a pulpotomy medicament in a permanent molar with pulpitis: a case report. Int Endod J. 2012; 45: 105-12.
20.Chang JD, Bird SR, Bohidar NR, King T. Analgesic efficacy of rofecoxib compared with codeine acetaminophen using a model of acute dental pain. Oral Surg Oral Med Oral Path Oral Radiol Endod. 2005; 100: 74- 80.
21. Mombelli A, Lang NP. Clinical parameters for the evaluation of dental implants. Periodontal. 2000 1994; 4: 81-6.
22. Abramoff MD, Magelhaes PJ, Ram SJ. Image Processing with Image J. Biophotonics Int. 2004; 11: 36-42.
23. Dias DR, Leles CR, Lindth C, Ribeiro-Rotta RF. The effect of marginal bone level changes on the stabilityof dental implants in a short-term evaluation. Clin Oral Impl Res. 2015; 26: 1185-90.
24. Akimoto K, Becker W, Persson R, Baker DA, Rohrer MD, O'Neal RB. Evaluation of titanium implants placed into simulated extraction sockets: a study in dogs. Int J Oral Maxillofac Implants. 1999; 14: 351-60.
25. Eriksson AR, Albrektsson T. Temperature threshold levels for heat-induced bone tissue injury: a vital-microscopic study in the rabbit. J Prosthet Dent. 1983; 50: 101-7.
26.Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, et al. Platelet rich fibrin (PRF): a secondgeneration platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 299-303. 27. Kumar N, Prasad K, Ramanujam L, K R, Dexith J, Chauhan A. Evaluation of treatment outcome after impacted mandibular third molar surgery with the use of autologous platelet rich fibrin: a randomized controlled clinical study. J Oral Maxillofac Surg. 2015; 73: 1042-9.
28.Jeong SM, Choi BH, Li J, Kim HS, Ko CY, Jung JH, et al. Flapless implant surgery: an experimental study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104: 24-8.
29. Wang RE, Lang NP. Ridge preservation after tooth extraction. Clin Oral Implants Res. 2012; 23: 147-56.
30. Kulkarni MR, Thomas BS, Varghese JM, Bhat GS. Plateletrich fibrin as an adjunct to palatal wound healing after harvesting a free gingival graft: A case series. J Indian Soc Periodontol 2014; 18: 399-402.
31. Yelamali T, Saikrishna D. Role of platelet rich fibrin and platelet rich plasma in wound healing of extracted third molar sockets: A comparative study. J Maxillofac Oral Surg. 2015; 14: 410-6.
32. Tsai CH, Shen SY, Zhao JH, Chang YC. Platelet-rich fibrin modulates cell proliferation of human periodontally related cells in vitro. J Dent Sci. 2009; 4: 130e5.
33. Toffler M, Toscano N, Holtzclaw D, Corso MD, Dohan DM. Introducing Choukroun's platelet rich fibrin (PRF) to the reconstructive surgery milieu. J Implant Adv Clin Dent. 2009; 1: 22-31.
34. Tatullo M, Marrelli M, Cassetta M, Pacifici A, Stefanelli LV, Scacco S, et al. Platelet Rich Fibrin (P.R.F) in reconstructive surgery of atrophied maxillary bones: Clinical and histological evaluations. Int J Med Sci. 2012; 9: 872-80.
35. Zhang Y, Tangl S, Huber CD, Lin Y, Qiu L, Rausch-Fan X. Effects of Choukroun’s platelet rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. J Craniomaxillofac Surg. 2012; 40: 321-8.
36. Quirynen M, Van Assche N, Botticelli D, Berglundh T. How does the timing of implant placement to extraction affect outcome? Int J Oral Maxillofac Implants. 2007; 22: 203-23.
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