Quantitative analysis of tissue regeneration after use of chitosan membrane versus collagen membrane in the management of grade II furcation defects in dogs | ||||
Alexandria Dental Journal | ||||
Article 13, Volume 42, Issue 2, December 2017, Page 204-209 PDF (617.99 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/adjalexu.2017.57928 | ||||
View on SCiNiTO | ||||
Authors | ||||
Fatma M Boker* 1; Maha A Abou-Khadr2; Hanna S Raslan3; Rania A Fahmy4 | ||||
1B.D.S. Faculty of Dentistry Benghazi University, Libya | ||||
2Professor of Periodontology, Oral Medicine, Oral Diagnosis and Radiology Alexandria university, Egypt | ||||
3Professor of Oral Pathology | ||||
4Lecturer of Periodontology, Oral Medicine, Oral Diagnosis and Radiology Alexandria university, Egypt. | ||||
Abstract | ||||
INTRODUCTION: Involvement of the furcations of multirooted teeth represents a challenge in the treatment of periodontal disease, both from a prognostic perspective and from the perspective of therapeutic measures. OBJECTIVES: the current investigation was conducted to evaluate the regenerative potential of chitosan membrane in the management of critical size grade II furcation defects and to compare it with conventional therapy using collagen membrane. MATERIALS AND METHODS: A total number of four adult systemically healthy mongrel dogs were included in the current study. Grade II critical-sized furcation defects were surgically created with respect to lower premolar teeth. In all four dogs, the right quadrants received chitosan membrane with natural hydroxyapatite. Whereas, the left quadrants received collagen membrane with natural hydroxyapatite. RESULTS: The present study observed that chitosan was better than collagen regarding mean bone surface area (P < 0.05) and the difference was statistically significant. CONCLUSIONS: Chitosan membrane is an effective, easy to handle, cheap membrane that can be used in periodontal regeneration of furcation defects. Chitosan membrane showed superior periodontal tissue regeneration when compared to collagen membrane in the mangement of such defects | ||||
Keywords | ||||
Chitosan; collagen; tissue regeneration; furcation defects | ||||
References | ||||
1. Kinane DF. Causation and pathogenesis of periodontal disease. Periodontol 2000 2001; 25: 8–20.
2. Shaila V, Kothiwale P, Anuroopa A, Gajiwala L. A clinical and radiological evaluation of DFDBA with amniotic membrane versus bovine derived xenografts with amniotic membrane in human periodontal grade II furcation defects. Cell Tissue Bank 2009; 10: 317–26.
3. Ponce CH, Domby EM, Anele UY, Schutz JS, Gautam KK, Galyean ML. Effects of bulk density of steam-flaked corn in diets containing wet corn gluten feed on feedlot cattle performance, carcass characteristics, apparent total tract digestibility, and ruminal fermentation. J Anim Sci 2013; 91: 3400-7.
4. Jepsen S, Eberhard J, Herrera D, Needleman I. A systematic review of guided tissue regeneration for periodontal furcation defects. What is the effect of guided tissue regeneration compared with surgical debridement in the treatment of furcation defects? J Clin Periodontol 2002; 29(Suppl 3): 103-16.
5. Gottlow J, Nyman S. Barrier membranes in the treatment of periodontal defects. Curr Opin Periodontol 1996; 3: 140-8.
6. Reynolds MA, Bowers GM. Periodontal regeneration following surgical treatment. Curr Opin Periodontol 1996; 3: 126-39.
7. Preeja C, Sivadas A. Platelet-rich fibrin: Its role in periodontal regeneration. Saudi J Dent Res 2014; 5: 117-22.
8. Wang HL, Cooke J. Periodontal regeneration techniques for treatment of periodontal diseases. Dent Clin North Am 2005; 49: 637-59.
9. Baskbutski JD, Wang HL. Periodontal and endodontic regeneration. J Endod 2009; 35: 321-8.
10.Buser D, Dula K, Belser U, Hirt HP, Berthold H. Localized ridge augmentation using guided bone regeneration. Int J Periodontics Restorative Dent 1993; 13: 29-45.
11. Schwartzmann M. Use of collagen membranes for guided bone regeneration: A review. Implant Dent 2000; 9: 63-6.
12. Norowski PA, Bumgardner JD. Biomaterial and antibiotic strategies for peri-implantitis. J Biomed Mater Res B Appl Biomater 2008; 88: 530-43.
13. Gomes S, Boulon M-E. Oliveira AL, Leonor IB, Mano JF, Reis RL. Mineralization of chitosan membrane using a double diffusion systemfor bone related applications. Mater Sci Forum 2008; 587: 77-81.
14.Chun X, Chang L, Liuyan M, Changning W, Yaling S. Chitosan as a barrier membrane material in periodontal tissue regeneration. J Biomed Mater Res B Appl Biomater 2012; 100: 1435-43.
15. Muzzarelli RA. Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone. Carbohydr Polym 2009; 76: 167-82.
16.Cui J, Liang J, Wen Y, Sun X, Li T, Zhang G, et al. In vitro and in vivo evaluation of chitosan/b-glycerol phosphate composite membrane for guided bone regeneration. J Biomed Mater Res Part A 2014; 102: 2911-7.
17. Tatakis DN, Promsudthi A, Wikesjo UME. Devices for periodontal regeneration. Periodontol 2000 1999; 19: 59- 73.
18. Teng S, Lee E, Wang P, Shin D, Kim H. Three-layered membranes of collagen/hydroxyapatite and chitosan for guided bone regeneration. J Biomed Mater Res B Appl Biomater 2008; 87: 132-8.
19.Jiang T, Kumbar SG, Nair LS, Laurencin CT. Biologically active chitosan systems for tissue engineering and regenerative medicine. Curr Top Med Chem 2008; 8: 354-64.
20. Wohlfahrt JC, Aass AM, Rønold HJ, Heijl L, Haugen HJ, Lyngstadaas SP. MicroCT and histological analysis of animal experimental Degree II furcation defects treated with porous titanium granules or deproteinized bovine bone J Periodontol 2012; 83: 211-21.
21. Abramoff MD, Magalhaes PJ, Ram SJ. Image Processing with Image J. Biophotonics Int 2004; 11: 36-42.
22. Kotz S, Balakrishnan N, Read CB, Vidakovic B. Encyclopedia of statistical sciences. 2nd ed. Hoboken, N.J.: Wiley-Interscience, 2006.
23. Kirkpatrick LA, Feeney BC. A simple guide to IBM SPSS statistics for version 20.0. Student ed. Belmont, Calif.: Wadsworth, Cengage Learning, 2013.
24.Cacchioli A, Spaggiari B, Ravanetti F, Martini FM, Borghetti P, Gabbi C. The critical sized bone defect: morphological study of bone healing. Ann Fac Medic Vet di Parma 2006; 26:97-110.
25. Hurzeler MB, Quinines CR, Caffesse RG, Schupbach P, Morrison EC. Guided periodontal tissue regeneration in class II furcation defects following treatment with a synthetic bioabsorbable barrier. J Periodontal 1997; 68: 498-505.
26. Pang EK, Paik JW, Kim SK, Jung UW, Kim CS, Cho KS, et al. Effects of chitosan on human periodontal ligament
27.fibroblasts in vitro and on bone formation in rat calvarial defects. J Periodontol 2005; 76: 1526-33.
28. Arancibia R1, Maturana C, Silva D, Tobar N, Tapia C, Salazar JC, et al. Effects of Chitosan Particles in Periodontal Pathogens and Gingival Fibroblasts. J Dent Res 2013; 92: 740-5.
29. Li X, Wang X, Zhao T, Gao B, Miao Y, Zhang D, et al. Guided bone regeneration using chitosan-collagen membranes in dog dehiscence-type defect model. J Oral Maxillofac Surg 2014; 72: 304.e1-14.
30. Tang SH, Lee EJ, Yoon BH, Shin DS, Kim HE, Oh JS. Chitosan/nanohydroxyapatite composite membranes via dynamic filtration for guided bone regeneration. J Biomed Mater Res A 2009; 88: 569-80.
31. Teng SH, Lee EJ, Wang P, Shin DS, Kim HE. Threelayered mem- branes of collagen/hydroxyapatite and chitosan for guided bone regeneration. J Biomed Mater Res B Appl Biomater 2008; 87: 132-8.
32. Lee EJ, Shin DS, Kim HE, Kim HW, Koh YH, Jang JH. Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. Biomaterials 2009; 30: 743-50.
33. Ku Y, Shim IK, Lee JY, Park YJ, Rhee SH, Nam SH, et al. Chitosan/ poly (L-lactic acid) multilayered membrane for guided tissue regeneration. J Biomed Mater Res A 2009; 90: 766-72.
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