Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives
Mhmood, H., Lafta, S., Atia, A., Al-Bayati, R., abdula, A. (2020). Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives. EKB Journal Management System, 63(1), 225-238. doi: 10.21608/ejchem.2019.16920.2030
Helen abdalhassan Mhmood; souad Jabbar Lafta; Abdul Jabar Khalf Atia; Redha Ibrahim Al-Bayati; ahmed mutanabbi abdula. "Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives". EKB Journal Management System, 63, 1, 2020, 225-238. doi: 10.21608/ejchem.2019.16920.2030
Mhmood, H., Lafta, S., Atia, A., Al-Bayati, R., abdula, A. (2020). 'Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives', EKB Journal Management System, 63(1), pp. 225-238. doi: 10.21608/ejchem.2019.16920.2030
Mhmood, H., Lafta, S., Atia, A., Al-Bayati, R., abdula, A. Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives. EKB Journal Management System, 2020; 63(1): 225-238. doi: 10.21608/ejchem.2019.16920.2030

Synthesis, Antimicrobial, Antioxidant and Docking Study of Novel 2H-1,4-Benzoxazin-3(4H)-One Derivatives

Egyptian Journal of Chemistry
Article 19, Volume 63, Issue 1, January 2020, Page 225-238  XML PDF (1.99 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.16920.2030
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Authors
Helen abdalhassan Mhmood email orcid 1; souad Jabbar Laftaorcid 2; Abdul Jabar Khalf Atia2; Redha Ibrahim Al-Bayati2; ahmed mutanabbi abdulaorcid 3
1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq
2Department of Chemistry, College of Science, Mustansiriyah University, Baghdad , Iraq.
3chemistry, college of science, Mustansiriyah university
Abstract
Abstract A novel series of 1,4-benzoxazinone derivatives were synthesized and characterized using FT-IR , 1H-NMR, 13C-NMR and Mass spectroscopy. These compounds were in vitro screened against several bacterial species gram positive and gram negative as well as Candida albicans and found exhibiting moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 1,1‐diphenyl‐2‐picryl hydrazyl (DPPH) radical. Docking study for the potent compound 8 against glucosamine-6-phosphate synthase , the target enzyme for the antimicrobial agents was explored to explain the interactions of the discovered hits with in the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compound as promising antimicrobial agents.
Keywords
Keywords: Antimicrobial; antioxidant; Docking study; 2-Aminophenol; Benzoxazinone; Hydrazide
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