Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines
Hassan, A., Ali, M., Diaa, M., Germoush, M., Mohamed, A., El-Sayed, W. (2020). Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines. EKB Journal Management System, 63(1), 247-253. doi: 10.21608/ejchem.2019.18248.2136
Amgad Hassan; Mamdouh Moawad Ali; Mohamed Diaa; Mousa O Germoush; Ashraf M Mohamed; Wael El-Sayed. "Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines". EKB Journal Management System, 63, 1, 2020, 247-253. doi: 10.21608/ejchem.2019.18248.2136
Hassan, A., Ali, M., Diaa, M., Germoush, M., Mohamed, A., El-Sayed, W. (2020). 'Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines', EKB Journal Management System, 63(1), pp. 247-253. doi: 10.21608/ejchem.2019.18248.2136
Hassan, A., Ali, M., Diaa, M., Germoush, M., Mohamed, A., El-Sayed, W. Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines. EKB Journal Management System, 2020; 63(1): 247-253. doi: 10.21608/ejchem.2019.18248.2136

Oxidative Stress of Some Triazolopyrimidine Derivatives and their Nucleoside Analogues on Mcf-7 and A549 Cell Lines

Egyptian Journal of Chemistry
Article 21, Volume 63, Issue 1, January 2020, Page 247-253  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.18248.2136
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Authors
Amgad Hassan email orcid 1; Mamdouh Moawad Aliorcid 2; Mohamed Diaaorcid 3; Mousa O Germoush4; Ashraf M Mohamedorcid 5; Wael El-Sayed6
1Biochemistry department- NRC- Egypt
2Biochemistry department -National Research Center (NRC).
3biochemistry department, National research center, Egypt.
4Biology Department, College of Science, Jouf University, Sakaka, 2014, Saudi Arabia.
5Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
6Photochemistry Department, Naional Research Centre, Dokki, Cairo, Egypt
Abstract
The synthesis and assessment of the biological benefits and applications of new triazolopyrimidines and their glycoside derivatives were discussed and researched thoroughly. Interestingly, the data revealed activity of these newly synthesized compounds in A549 and MCF-7 cell lines, where MCF-7 cells responded more effectively to the examined compounds than the other cell lines. The present work’s aim is to appraise the behavior of some free radical enzymes, including SOD, CAT, GSH-Px and oxidative stress parameters H2O2, NO, GSH in MCF-7 and A549 treated cells. The results brought out that, there is an increase in the level of H2O2 and NO associated with an acme in the SOD enzyme activity, besides there is a diminution in the activities of CAT, GSH and GSH-Px when we compared it with control. These results may indicate that compounds 1, 2, 3 and 4 may exert their anticancer activities - to some extent – through the inflection of both the production of reactive oxygen species (ROS) and the action of antioxidant enzymes
Keywords
Triazolopyrimidines; Cancer; Oxidative Stress; anti-oxidants; MCF-7; A549
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