EVALUATION OF THE EFFECT OF CHOLECALCIFEROL ON TITANIUM IMPLANT OSSEOINTEGRATION (AN EXPERIMENTAL STUDY) | ||||
| Alexandria Dental Journal | ||||
| Article 6, Volume 40, Issue 1, July 2015, Page 33-39 PDF (463.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2015.58732 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| M Gaber1; M Saleh2; G Elba3 | ||||
| 1B.D.S. 2006, Alexandria University | ||||
| 2Professor of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Alexandria University. | ||||
| 3Professor of Oral Biology, Department of Oral Biology, Alexandria University | ||||
| Abstract | ||||
| Introduction: Cholecalciferol (Vitamin D3) is essential for bone mineralization and for the subsequent maintenance of bone quality. Supplementation with Cholecalciferol (vitamin D3) is reported to show positive effects on bone mineral density Objectives: Evaluation of the effect of Cholecalciferol on dental implant osseointegration. Materials and Methods: The study was conducted on fourteen adult male mongrel dogs.Dogs were divided equally into two groups, control group and study group, seven dogs in each group. Extraction of mandibular right premolar and insertion of immediate titanium implant had been done for all dogs in both groups, and then only the dogs of the study group received Cholecalciferol for four weeks. Histological and radiographical evaluations were carried out after twelve weeks postoperatively for both groups. Results: Histological results revealed improved bone healing in the study group, as shown by marked osteoblastic activity and accelerated woven bone formation, and absence of chronic inflammatory cells. The highest rate of bone ingrowth occurred in the study group. Radiograghical evaluation revealed that the peri-implant bone density had increased significantly in the study group. Conclusion: These results indicated that Cholecalciferol vitamin D3 has systemic effects on accelerating bone formation around titanium implant | ||||
| Keywords | ||||
| Cholecalciferol; vitamin D3; Dental implants; osseointegration | ||||
| References | ||||
|
1. lsaksson S. evaluation of three bone grafting techniques for severely resorbed maxilla in conjunction with immediate endosseous implants. Int J Oral maxillofac Implants 1994; 9: 679-88. 2. Schwartz-Arade D, Chuashu G. The ways wherefores of immediate placement of implant into fresh extraction sites: A literature review. J periodontal 1997; 86: 915- 23 3. Marco F, Milena F, Gianluca G, Vittoria O. Periimplant osteogenesis in health and osteoporosis. Micron 2005; 36: 630-44.
4. Linder L, Obrant K, Boivin G. Osseointegration of metallic implants. II. Transmission electron microscopy in the rabbit. Acta Orthop Scand 1989; 60: 135-9. 5. Soballe K. Hydroxyapatite ceramic coating for bone implant fixation. Mechanical and histological studies in dogs. Acta Orthop Scand Suppl 1993; 255: 1-58. 6. Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM. The biology of bone grafting. J Am Acad Orthop Surg 2005; 13: 77-86. 7. Arrington ED, Smith WJ, Chambers HG, Bucknell AL, Davino NA. Complications of iliac crest bone graft harvesting. Clin Orthop 1996; 329: 300-9. 8. Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma 1989; 3: 192-5. 9. Eberhardt C, Habermann B, Müller S, Schwarz M, Bauss F, Kurth AH. The bisphosphonate ibandronate accelerates osseointegration of hydroxyapatite-coated cementless implants in an animal model. J Orthop Sci 2007; 12: 61-6. 10. Başarir K, Erdemli B, Can A, Erdemli E, Zeyrek T. Osseointegration in arthroplasty: can simvastatin promote bone response to implants? Int Orthop 2009; 33: 855-9. 11. Viljakainen HT, Natri AM, Kärkkäinen M, Huttunen MM, Palssa A, Jakobsen J et al. A positive dose- response effect of vitamin D supplementation on site- specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res 2006 ; 21: 836-44. 12. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 1997; 337: 670-6. 13. Baeksgaard L, Andersen KP, Hyldstrup L. Calcium and vitamin D supplementation increases Spinal BMD in healthy postmenopausal women. Osteoporos Int 1998; 8: 255-60. 14. Kumar PT, Antony S, Nandhu MS, Sadanandan J, Naijil G, Paulose CS. Vitamin D3 restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats. J Nutr Biochem 2011; 22: 418-25. 15. Schedlich LJ, Muthukaruppan A, O'Han MK, Baxter RC. Insulin-like growth factor binding protein-5 interacts with the vitamin D receptor and modulates the vitamin D response in osteoblasts. Mol Endocrinol 2007; 21: 2378-90. 16. Baas D, Prüfer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarliève LL et al. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25- dihydroxyvitamin D(3). Glia. 2000; 31: 59-68. 17. Becker A, Eyles DW, McGrath JJ, Grecksch G. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res 2005; 161: 306-12. 18. Garcion E, Nataf S, Berod A, Darcy F, Brachet P. 1,25- Dihydroxyvitamin D3 inhibits the expression of inducible nitric oxide synthase in rat central nervous system during experimental allergic encephalomyelitis. Brain Res Mol Brain Res 1997; 45: 255-67. 19. Landfield PW, Applegate MD, Schmitzer-Osborne SE, Naylor CE. Phosphate/calcium alterations in the first stages of Alzheimer's disease: implications for etiology and pathogenesis. J Neurol Sci 1991; 106: 221-9. 20. Rapuri PB, Gallagher JC, Nawaz Z. Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells. J Steroid Biochem Mol Biol 2007; 103: 368-71. 21. Misof BM, Roschger P, Tesch W, Baldock PA, Valenta A, Messmer P, et al. Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals. Calcif Tissue Int 2003; 73: 2517. 22. Kraichely DM, MacDonald PN. Transcriptional activation through the vitamin D receptor in osteoblasts. Front Biosci 1998; 3: 821-33. 23. McCarty MF. Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians. Med Hypotheses 2009; 72: 647-51. 24. Seshadri KG, Tamilselvan B, Rajendran A. Role of vitamin D in diabetes. J Endocrinol Metab 2011; 1: 47-56. 25. Davies JE. Mechanisms of endosseous integration. Int J Prosthodont 1998; 11: 391-401. 26. Gailit J, Clark RA. Wound repair in the context of extracellular matrix. Curr Opin Cell Biol 1994; 6:717-25. 27. Franchi M, Fini M, Martini D, Orsini E, Leonardi L, Ruggeri A, et al. Biological fixation of endosseous implants. Micron 2005; 36: 665-71 28. Murai K, Takeshita F, Ayukawa Y, Kiyoshima T, Suetsugu T, Tanaka T. Light and electron microscopic studies of bone-titanium interface in the tibiae of young and mature rats. J Biomed Mater Res 1996; 30:523-33. 29. Probst A, Spiegel HU. Cellular mechanisms of bone repair. J Invest Surg 1997; 10:77-86. 30. Roux C, Bischoff-Ferrari HA, Papapoulos SE, de Papp AE, West JA, Bouillon R. New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin 2008; 24: 1363–70. 31. Brinker MR, O’Connor DP, Monla YT, Earthman TP. Metabolic and endocrine abnormalities in patients with nonunions. J Orthop Trauma 2007; 21: 557–70. 32. Kelly J, Lin A, Wang CJ, Park S, Nishimura I. Vitamin D and bone physiology: demonstration of vitamin D deficiency in an implant osseointegration rat model. J Prosthodont 2009 18: 473–8. 33. Fu L, Tang T, Miao Y, Hao Y, Dai K. Effect of 1,25- dihydroxy vitamin D3 on fracturehealing and bone remodeling in ovariectomized rat femora. Bone 2009; 44: 893–8. 34. Abrahamsson I, Berglundh T, Moon IS, Lindhe J. Peri- implant tissues at submerged and nonsubmerged titanium implants. J Clin Periodontol 1999; 26: 600–7. 35. Vercaigne S, Wolke JGC, Naert I, Jansen JA. The effect of titanium plasma-sprayed implants on trabecular bone healing in the goat. Biomaterials 1998; 19: 1093–9. 36. Davies JE. Understanding peri-implant endosseous healing. J Dent Educ 2003; 67: 932–49. | ||||
|
Statistics Article View: 200 PDF Download: 450 |
||||
