EFFECT OF ASPIRIN ON THE PROLIFERATION PARAMETERS OF RAT COLONIC CRYPTS: A HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY | ||||
| The Egyptian Journal of Anatomy | ||||
| Article 7, Volume 26, Issue 1, January 2003, Page 171-194 PDF (3.85 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejana.2003.5875 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Dina Radwan; Hanan Amin; Ashraf Kamel | ||||
| Histology Department, Faculty of Medicine. Cairo University | ||||
| Abstract | ||||
| Tumorgenesis has been recognized for years as a multistep process. accompanied by accumulation of mutations and changes in oncogenes and tumor suppressor genes leading to changes in behaviour of the affected cell and transformation into malignant cell (Shpltz et al., 1995). One cf the mechanisms that contributes to malignant transformation is increased cell proliferation (Hall & Coates, 1995), Gastrointestinal tract epithelium is characterized by active and rapid cell turnover. During their growth, proliferating cells divide by the cell cycle which is controlled by numerous regulatory proteins such as oncoproteins and cyclins including the proliferating cell nuclear antigen (PCNA) (Murakami et al., 1995). Despite the most recent technologic advances. cancer of the large bowel is still a major cause of neoplastic morbidity and mortality. The first step in multistage colonic carcinogenesis is increased cell proliferation and an upward shift of the proliferating zone in colonic crypts (Shpitz et al., 1997). Aspirin (acetylsalicylic acid) has been well known for its anti-pyretic and antiinflammatory action over the past century. However, in recent years there has been an evidence suggesting that aspirin could reduce the risk of colorecral cancer but the exact mechanism by which aspirin exerts this chemopreventive effect is unclear and complex (Law et al., 2000). Therefore, this work was designed to assess the effect of aspirin intake on epithelial cell proliferation in the colonic crypts of adult rats aiming at clarifying how aspirin protects against development of cancer colon. | ||||
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