Hodgkin Lymphoma Presenting as Hemophagocytic Lymphohistiocytosis: A Case Report and Review of Published Cases | ||||
| Research in Oncology | ||||
| Article 6, Volume 12, Issue 1, June 2016, Page 28-30 PDF (414.95 K) | ||||
| Document Type: Case reports | ||||
| DOI: 10.21608/resoncol.2016.591 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Somaia Mousa  
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| Clinical Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a serious syndrome that occurs in association with malignancy, infections and autoimmune diseases. Case presentation: A 30 years old female patient presented with fever, splenomegaly, pancytopenia, hyperferritinemia, hypertriglyceridemia and hemophagocytosis in bone marrow aspirate. She was initially diagnosed as HLH. Bone marrow biopsy revealed the presence of Hodgkin lymphoma. Discussion: The most common HLH associated-malignancy is T/natural killer cell lymphoma and less commonly diffuse large B-cell lymphoma. The combination of HLH and Hodgkin lymphoma is rare. A strong association between Hodgkin lymphoma associated HLH and Epstein Barr virus (EBV) infection has been discussed in published case reports. Hodgkin lymphoma may be a cause of HLH and their relation with EBV has to be investigated. | ||||
| Keywords | ||||
| Hemophagocytic lymphohistiocytosis (HLH); Hodgkin Lymphoma; Epstein Barr virus (EBV) | ||||
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