EVALUATION OF TOPICAL OZONE THERAPY ON HEALING OF MANDIBULAR BONY DEFECTS | ||||
| Alexandria Dental Journal | ||||
| Article 3, Volume 40, Issue 2, December 2015, Page 148-152 PDF (1.22 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2015.59133 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S.T Mohamed* ; A.A Sharara* ; H.R Ragab* ; N.M Zahran* | ||||
| B.D.S. Faculty of Dentistry, Alexandria University | ||||
| Abstract | ||||
| Introduction: Bone defects are commonly found in oral cavity, they may have functional or esthetical problems that need surgical intervention. The emergence of ozone therapy seems to be a promising future in different dental modalities that may be effective in treating bony defects. Objective: To evaluate histologically the effect of topical administration of ozone therapy; on healing of experimentally-induced mandibular bone defects; in dogs. Materials and methods: A split mouth design was carried out below the 4th mandibular premolar of six healthy mongrel dogs. A total of 12 bony defects were surgically created. After reflecting the mucoperiosteal flap, the defects in the right side were treated with ozonated gel and those in the left side did not receive any treatment. Two dogs were sacrificed after 2, 6, 12 weeks. Samples were dissected and prepared for histological evaluation Results: The study revealed that using ozone gel in bony mandibular defects accelerates the onset of new bone formation and increases vascularization at the injured site. Conclusion: Ozone is a beneficial agent to avoid possible complications and to have better chance for soft and hard tissue healing. | ||||
| Keywords | ||||
| Ozone gel; bony defect; Histological examination | ||||
| References | ||||
|
1. Kruger F. Reconstruction of bone and soft tissue in extensive facial defects. J Oral Maxillofac Surg 1982; 40: 717-20.
2. Kluft O, van Dop F. Mandibular ameloblastoma (resection with reconstruction): a case report with concise review of the literature. Arch Chiv Nearl 1970; 8: 114.
3. Zhao Y, Zhang W, Zhao JH. Reconstruction of intra oral defects after cancer surgery. J Oral Maxillofac Surg 2001; 59: 1142-6.
4. Blackwell KE, Buchbinder D, Biller HF, Urken ML. Reconstruction of massive defects in the head and neck: the role of simultaneous distant and regional flaps. Head Neck 1997; 19: 620-8.
5. Bocci VA. Tropospheric ozone toxicity vs. usefulness of ozone therapy. Arch Med Res 2007; 38: 265-7.
6. Hunter B. Ozone application: An In-Depth discussion. Health Freedom News 1995; 15: 189-96.
7. Viebahn R. The use of ozone in medicine. 2nd ed.Heidleberg, Germany: Karl F. Hanf publishers GmbH & co., 1987.
8. Harken M. Factors influencing the ozone inactivation of enteric viruses in effluent. Ozone: Science and Engineering 1985; 6: 235-43.
9. Menendez CO, Martinez ME, Claverat T. Application of ozonized oil in the treatment of alveolitis, 2nd international symposium on ozone applications. Havana, Cuba: 1997.
10. Knoch G, Roschke W, Klug W. Ozone/oxygen therapy in proctology. Ozona Chrichten 1987; 6: 635-41.
11. Viebahn-hunster R. Ozone therapy: the underlying therapeutically concept and models of efficacy. Erfahr ungsheilkunde 1991; 40: 871-24.
12. Ashour E. Healing of osseous defects using demineralized freeze-dried bone with resorbable and non resorbable membranes. M. Sc. Thesis. Oral Surgery Department, Faculty of Dentistry, Alex University. 2000.
13. Huth KC, Jakob FM, Saugel B, et al. Effect of ozone on oral cells compared with established antimicrobials. Eur J Oral Sci 2006; 114: 435.
14. Aerssens J, Boonen S, Lowet G, Dequeker J. Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research. Endocrinology 1998; 139: 663-70.
15. Pillipi A. Ozone in oral surgery. Current status and prospects. Ozone Sci Engin 1997; 19: 387-93.
16. San Severino ER. Knee-joint disorders treated by oxygen-ozone therapy. Euorpa Medico Physica 1989; 25: 163-70.
17. Silivia M, Olgac, Odalys R, Labaut D, Odalys C, Laura E, Wilfredo D. application of ozonized oil in the treatment of infected ridicule conduits, Ozone research center. National center for scientific research,. Elpidio Berovides Polyclinic 1995; 3: 84-9.
18. Hendy Z. Effect of ozone gel and bioactive glass with ozone gel on healing of bone defects on experimental animals. M.Sc. Thesis. Faculty of Dentistry, Alexandria University. 2009.
19. Kayed S. Evaluation of the effect of ozone gel after surgical removal of impacted lower third molar. M.Sc. Thesis. Faculty of Dentistry, Alexandria University. 2009.
20. Hunter B. Ozone application: An in-Depth Discussion. Health Freedom News 1995; 14: 189-96.
21. Hebal MB. Advances in plastic and reconstructive surgery. Chicago YBMB 1989; 5: 244.
22. Kotze M, Bütow KW, Olorunju SA, Kotze HF. Ozone treatment of alveolar bone in the Cape Chacma baboon does not enhance healing following trauma. J Maxillofac Oral Surg 2014; 13: 140-7.
23. El Kazzaz N. Evaluation of the effect of ozone administration in diabetic induced rats. M.Sc. Thesis. Faculty of Dentistry, Alexandria University. 2009.
24. Sorokina S, Lukinych L. Ozone Therapy as a Part of a Complex Treatment of a Paradontium Disease. The Medical Academy of Nizhni Novgorod, Russia. 2nd international symposium on ozone application. Havana, Cuba. 1997.
25. Nagayoshi M, Fukuizumi T, Kitamura C, Yano J, Terashita M, Nishihara T. Efficacy of ozone on survival and permeability of oral microorganisms. Oral Microbiol Immunol 2004; 19: 240-6.
26. Nogales CG, Ferrari PH, Kantorovich EO, LageMarques JL. Ozone therapy in medicine and dentistry. J Contemp Dent Pract 2008; 9: 75-84. | ||||
|
Statistics Article View: 136 PDF Download: 648 |
||||
