Investigation of In-Vitro Cytotoxic and Potential Anticancer Activities of Flavonoidal Aglycones from Egyptian Propolis | ||||
Records of Pharmaceutical and Biomedical Sciences | ||||
Article 3, Volume 1, Issue 2, September 2017, Page 13-20 PDF (860.7 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/rpbs.2018.5924 | ||||
View on SCiNiTO | ||||
Authors | ||||
Reham Ibrahim 1; Ahmed Seif El-Din2; Marwa Abu-Serie3; Nevine Abd El Rahman4; Maha El-Demellawy3, 5; Aly Metwally2 | ||||
1Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria 21521, Egypt | ||||
2Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt | ||||
3Medical Biotechnolog Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City, Egypt | ||||
4Pharmaceutical & Fermentation Industries Development Center, City of Scientifc Research and Technological Applications, Alexandria, Egypt | ||||
5Pharmaceutical & Fermentation Industries Development Center, City of Scientific Research and Technological Applications, Alexandria, Egypt | ||||
Abstract | ||||
The in-vitro anticancer activity of Egyptian propolis ethanol extract as well as two isolated flavonoidal aglycones, tectochrysin and quercetin-3,3’-di-O-methylether,was assayed using neutral red uptake method on human breast cancer (MCF-7) and colorectal adenocarcinoma (Caco-2) cell lines, in addition to their in-vitro cytotoxic effect to normal human peripheral blood mononuclear cells (PBMCs). Egyptian propolis ethanol extract and quercetin-3,3’-di-O-methylether showed both high activity and selectivity towards the two tested cell lines suggesting them as effective, safe and selective anticancer candidates against both breast and colorectal cancer. | ||||
Keywords | ||||
Propolis; Flavonoidal aglycones; In-vitro anticancer activity | ||||
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