Possible Effects of Growth Hormone Therapy on the Eye | ||||
| The Medical Journal of Cairo University | ||||
| Article 29, Volume 87, September, September 2019, Page 2963-2966 PDF (164.68 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2019.59336 | ||||
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| Authors | ||||
| AHMED FAWZY, M.Sc.; NORA EL-SAID BADAWI, M.D.; MOHAMED M. ISMAIL, M.D.; MOATAZ HAMED OSMAN, M.D. | ||||
| The Departments of Pediatrics* and Ophthalmology**, Faculty of Medicine, Cairo University | ||||
| Abstract | ||||
| Abstract Background: Human growth hormone therapy in children may affect the eye due to its growth promoting properties. Aim of the Study: To detect possible effects of growth hormone therapy on ocular axial length, refraction and posterior segment. Patients and Methods: This study included 30 Growth Hormone (GH) deficient children scheduled for human GH therapy. Before GH treatment patients ocular examination included: Dilated fundus, cycloplegic spherical equivalent and axial length using A-scan ultra sound. All the previous examination items were repeated and documented 6 months after treatment start. Results: 30 GH deficient children were included; 17 (56.7%) males and 13 (43.3%) females of whom 3 had turner syndrome. Mean age was 11 .39±3.64 years. Mean spherical equivalent of cycloplegic refraction was +0.81-}0.85 diopter pre-therapy and +0.26-}0.6 diopter 6 months after therapy (p-value=0.2). Mean axial length was 21.04-}1.33mm pre-therapy and 21.421.39mm 6 months after therapy (p-value=0. 12). Right sided papilledema occurred in 1 patient with turner syndrome (1.66%) 6 months after therapy, while no other retinal complications were found. Conclusion: We found no significant change in ocular axial length and refraction 6 months after GH therapy. One case of pseudotumour cerebri was documented. We recommend routine fundus examination for patients receiving GH therapy and stop of therapy once papilloedema encountered. | ||||
| Keywords | ||||
| Growth hormone; Papilloedema; Axial length; Cycloplegic refraction; Pseudotumour cerebri | ||||
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