THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY
Badr, O., Shirefa, E., Khamis, O. (2016). THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY. EKB Journal Management System, 2(Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology), 46-59. doi: 10.21608/rjab.2016.59548
Osama M. Badr; Eman M. Shirefa; Omaima A. Khamis. "THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY". EKB Journal Management System, 2, Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology, 2016, 46-59. doi: 10.21608/rjab.2016.59548
Badr, O., Shirefa, E., Khamis, O. (2016). 'THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY', EKB Journal Management System, 2(Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology), pp. 46-59. doi: 10.21608/rjab.2016.59548
Badr, O., Shirefa, E., Khamis, O. THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY. EKB Journal Management System, 2016; 2(Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology): 46-59. doi: 10.21608/rjab.2016.59548

THE CURATIVE ROLE OF CURCUMIN AND FLAXSEED EXTRACTS IN MICE INOCULATED WITH EAC: BIOCHEMICAL AND HISTOLOGICAL STUDY

Research Journal of Applied Biotechnology
Article 6, Volume 2, Special issue (1) for the first International Conference of Genetic Engineering and Biotechnology, November 2016, Page 46-59  XML PDF (2.13 MB)
Document Type: Original Article
DOI: 10.21608/rjab.2016.59548
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Authors
Osama M. Badr email ; Eman M. Shirefa; Omaima A. Khamis
Department of Animal Biotechnology, Genetic Engineering & Biotechnology Institute, University of Sadat City, Sadat City, Minufiya Province, Egypt.
Abstract
This investigation discussed the role of curcumin and flaxseed in defeating induced solid tumours with the subcutaneous inoculation of mice with Ehrlich Ascites Carcinoma (EAC) in a definite volume (3X106 cells). Once the tumours were formed, the mice were divided into four groups (control, tumour untreated, curcumin and flaxseed) groups. Each group contains six mice. By the end of experimentation (28 days) after tumour formation, mice were dissected and histological examination for liver and kidney were performed in all groups. Also, the levels of liver functions (ALT & AST), kidney functions (Urea & Creatinine), oxidant and antioxidant enzymes (MDA, SOD and CAT) were measured in all tested groups. This study could state that Curcumin and flaxseed modulated the histological structures of both liver and kidney close to normal patterns. Also, treatments could modified the elevated values of (ALT, AST, Urea, Creatinine and MDA) and decreased levels of (SOD and CAT) towards the normal values. Treatments with Curcumin and flaxseed also reduced the tumour volumes significantly.
Keywords
Curcumin; Flaxseed; Liver; kidney; Ehrlich Ascites Carcinoma (EAC); solid tumour; alanine transaminase (ALT); aminotransferase (AST); urea; creatinine; Malondialdehyde (MDA); superoxide dismutase (SOD) and catalase (CAT)
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