Serum Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Early Renal Dysfunction in Adult Egyptian Patients with b-Thalassemia Major | ||||
| The Medical Journal of Cairo University | ||||
| Article 82, Volume 86, September, September 2018, Page 2811-2814 PDF (348.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.59622 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| NELLY D. EL-SHALL, M.D.; AMAL S. EL-BENDARY, M.D.; HANAA I. OKDA, M.D.; KAREEM A. EL-ASHRY, M.Sc. | ||||
| The Department of Internal Medicine, Faculty of Medicine, Tanta University | ||||
| Abstract | ||||
| Abstract Background: Renal dysfunction in thalassemia may occur before the occurrence of any symptoms, Induction of NGAL after kidney injury precedes the elevation of classical markers for kidney damage, which made it a promising marker for renal dysfunction in b-thalassemia, major. Aim of the Work: To assess value of serum NGAL in patients with b-thalassemia major as an early marker of renal impairment. Patients and Methods: The present study enrolled 70 subjects and they were classified into two main groups: •Group (I): 20 apparently healthy normal volunteers. •Group (II): 50 multi-transfused b-thalassemia major patients. Which subdivided according to chelation therapy into two subgroups: •Subgroup (I): On regular iron chelation therapy. •Subgroup (II): Without chelation therapy. Results: In our study serum NGAL was significantly elevated in group II compared to control group. Also in our study, we found a direct correlation between NGAL and urea, creatinine, eGFR, ferritin, transferrin saturation while there was inverse correlation between NGAL and hemoglobin, b2- microglobulin. Conclusion: NGAL could be considered as early predictor of renal dysfunction in thalassemia. | ||||
| Keywords | ||||
| Thalassemia major – Renal dysfunction – NGAL | ||||
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