Assessment of Galectin-3 Levels in Psoriasis Vulgaris | ||||
| Zagazig University Medical Journal | ||||
| Article 7, Volume 28, Issue 6.2, November 2022, Page 35-39 PDF (364.7 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2019.16276.1459 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sukina Abdalla Alhabib  1; Mohamed Hamed Khater2; Fathia Khattab 3; Kamal Ahmad Elkshishy4
| ||||
| 1Medical Arab University, Faculty of Medicine, Dermatology, Venereology and Andrology | ||||
| 2Assistant professor of Dermatology, Venereology and Andrology, Faculty of Medicine - Zagazig University | ||||
| 3Assistant Professor, Dermatology department,Zagazig univeristy: Zagazig, zagazig | ||||
| 4Professor of Pathology, Faculty of Medicine - Zagazig University | ||||
| Abstract | ||||
| Background: Galectin-3 is a one of the galectin family and produced by T-lymphocytes and has an important role in the inflammation process. Aim: the aim of this study was to determine the levels of serum galectin-3 in patients with psoriasis Vulgaris, a T-cell-mediated inflammatory disease, and investigate the correlation between these levels and activity of disease. Material and Method: this study included thirty-six patients with psoriasis Vulgaris and 30 healthy subjects. The psoriasis area and severity index (PASI) were calculated and recorded for every patient. The patients were divided into three groups; group I (mild), II (moderate) and III (Severe) according to the PASI scores. ELISA analysis was used to analyze the level of serum galectin-3. Results: level of serum galectin-3 in psoriasis Vulgaris patients was significantly lower than the control group (p=0.001). there was a negative correlation between level of serum galectin-3 and PASI scores (Spearman's rho=-0.749, P | ||||
| Keywords | ||||
| PASI score; Psoriasis; galectin 3 | ||||
|
Statistics Article View: 276 PDF Download: 88 |
||||
