Circulating CD4+ CD28 Null T Cells and CD4+ CD28+ T Lymphocytes in Systemic Lupus Erythematosis | ||||
| The Medical Journal of Cairo University | ||||
| Article 50, Volume 86, December, December 2018, Page 3787-3791 PDF (557.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.61495 | ||||
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| Authors | ||||
| MAHA A. BASSIOUNY, M.D.; ENAS S. ESSA, M.D.; KHALED M.A. EL-ZORKANY, M.D.; DOAA M.S. EL-SAYED, M.Sc. | ||||
| The Departments of Clinical Pathology* and Internal Medicine**, Faculty of Medicine, Menoufia University, Menoufia, Egypt | ||||
| Abstract | ||||
| Abstract Background: Systemic Lupus Erythematosis (SLE) is a chronic multi factorial systemic autoimmune disease which affects multiple organs such as joints, the skin, kidneys or central nervous system. T cells may be a contributing factor in pathogenesis of SLE. Aim of Study: The objective of this study was to evaluate senescent CD4+ CD28 null T lymphocytes and conventional CD4+ CD28+ T lymphocytes in SLE patients with and without nephritis. Subjects and Methods: The study was conducted on 51 patients with SLE; 21 patients with nephritis and 30 patients without nephritis, in addition to 15 age and sex matched healthy individuals as control. The CD4/CD28 expression on peripheral blood lymphocytes was measured for all study subjects using flowcytometry technique. Results: CD4+/CD28 null T-lymphocytes showed no statistically significant difference among the studied groups. Meanwhile, CD4+/CD28+ T lymphocytes were significantly higher SLE patients with nephritis than controls (p=0.009). There was significant positive correlation between CD4+/ CD28+ T lymphocyte population size and serum creatinine in SLE with nephritis (p=0.004). Conclusion: CD4+/CD28+ T lymphocyte population was higher in SLE patients with nephritis than controls and show statistically significant changes in correlation with serum creatinine level. | ||||
| Keywords | ||||
| CD4+/CD28+ – CD4+/CD28null – Lupus – Nephritis – T-lymphocytes | ||||
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