The Role of Magnetic Resonance Imaging in the Evaluation of Children with Cerebral Palsy: A Proton Magnetic Resonance Spectroscopy Study | ||||
| The Medical Journal of Cairo University | ||||
| Article 55, Volume 86, December, December 2018, Page 3833-3838 PDF (758.68 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2018.61852 | ||||
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| Authors | ||||
| RANIA S. ABOUKHADRAH, M.D.; NOHA M. ABD EL-MABOUD, M.D.; AL-SHYMAA ZAKREYA AL-SHAHAWY, M.D. | ||||
| The Department of Radio-Diagnosis and Medical Imaging, Faculty of Medicine, Tanta University, Tanta, Egypt | ||||
| Abstract | ||||
| Abstract Background: Study of brain metabolites using 1 HMRS in children with cerebral palsy. Aim of Work: To study the metabolite changes in the basal ganglia of children with CP in comparison with a normal control group of the same age by using proton magnetic resonance spectroscopy (1HMRS). Material and Methods: Thirty children with different types of CP with associated developmental delay were exam-ined. Different types of CP were included (spastic, dyskinetic, dystonic or choreo-athetoid and ataxic CP). The control group consisted of twenty normally developing children. The relative concentrations of N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr) and their combinations within 1 cm3 brain multi voxels were measured. Results: Children with CP showed reduced ratios of NAA: Cr, NAA: Cho, mI: Cr in the basal ganglia and the increased ratio of NAA: mI and CHO: CR in relation to that of the control group. There was age-dependency increase in NAA: Cr and NAA: Cho in the basal ganglia. Metabolites ratio differs according to the severity of CP. Conclusion: MRS plays a promising role in evaluating children with cerebral palsy and also in determining the degree of learning disability aiming at a better rehabilitation of children with CP. | ||||
| Keywords | ||||
| Cerebral palsy – MRS – Basal ganglia | ||||
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