The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency
Kassem, M., Nasr, M., Sadik, K., Belal, S. (2019). The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency. EKB Journal Management System, 2(2), 19-23. doi: 10.21608/djvs.2019.62120
Mostafa Kassem; Mohamed Nasr; Kadry Sadik; Shrouk Belal. "The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency". EKB Journal Management System, 2, 2, 2019, 19-23. doi: 10.21608/djvs.2019.62120
Kassem, M., Nasr, M., Sadik, K., Belal, S. (2019). 'The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency', EKB Journal Management System, 2(2), pp. 19-23. doi: 10.21608/djvs.2019.62120
Kassem, M., Nasr, M., Sadik, K., Belal, S. The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency. EKB Journal Management System, 2019; 2(2): 19-23. doi: 10.21608/djvs.2019.62120

The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency

Damanhour Journal of Veterinary Sciences
Article 5, Volume 2, Issue 2, November 2019, Pages 19-23    PDF (178.37 K)
Document Type: Original Article
DOI: 10.21608/djvs.2019.62120
Authors
Mostafa Kassem1; Mohamed Nasr2; Kadry Sadik3; Shrouk Belal* 4
1Surgery Department, Faculty of Veterinary Medicine, Alexandria University
2Animal Medicine Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt
3Biochemistry Department, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt
4Food Safety and Hygiene Laboratory, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, El-Behera, Egypt
Abstract
The present study was aimed to evaluate anesthetic properties, clinic-physiological and hemato-biochemical effects of propofol alone, thiopental alone or propofol/thiopental mixture in dogs with experimental liver insufficiency. For this purpose, 9 apparently healthy male dogs exposure to electrocauterization to induce liver insufficiency model.   The dogs were randomly divided into three groups; each group consists of three dogs.  All dogs were premedicated with Xylazine Hcl (1mg/kg bwt/i.m). The induction of general anesthesia was done via i/v injection of 6 mg/kg bwt Propofol (group A); 5mg/kg bwt Thiopental (group B) and 3 mg/kg Propofol + 2.5 mg/kg Thiopental mixture (group C). Blood samples were collected from the three groups at15mins before anesthesia induction then at 15, 30 and 45 minutes after treatments for both clinico-physiological and hemato-biochemical evaluations. A mild alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction in all groups, but it still safe induce general anesthesia in dogs affected with liver insufficiency. However, Propofol /Thiopental mixture was induced a rapid, smooth induction and a longer duration of anesthesia with complete muscle relaxation which is suitable for all most surgical operations.
Keywords
Thiopental; propofol; Propofol/Thiopental mixture; Liver Insufficiency; dogs
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