Optical Coherence Tomography Angiography Compared to Fluorescein Angiography in Central Retinal Vein Occlusion | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 13, Volume 77, Issue 5, October 2019, Page 5611-5620 PDF (478.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2019.62142 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Khaled Selim1; Mostafa Mahmoud1; Ali Maher Ibrahim El-Shaarawy  2
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| 1Department of Ophthalmology, Faculty of Medicine, Al-Azhar University | ||||
| 2Memorial Institute of Ophthalmic Research | ||||
| Abstract | ||||
| Background: Retinal vein occlusion is the second most common cause of retinal vascular disease worldwide after diabetic retinopathy. Objective: It is a prospective comparative study to evaluate the optical coherence tomography angiography appearance of superficial and deep capillary plexa in eyes with central retinal vein occlusion in comparison to conventional finding in fluorescein angiography. The study was approved by the medical ethics committee of Al-Azhar University Hospitals and a written informed consent is obtained from all patients. Patients and Methods: A total of 19 eyes of 17 patients (with a known clinical diagnosis of CRVO; any stage, any type), were recruited. All patients underwent standard ophthalmological examination together with multimodal imaging procedures including; color fundus photography, fluorescein angiography and optical coherence tomography angiography. Quantitative flow analysis of the SCP has been performed for selected 15 images of 15 eyes with CRVO versus a single eye of a normal control. Results: Optical coherence tomography angiography can qualitatively demonstrate all the macular complications of CRVO including; ischemia, capillary dilation, microaneurysms, collateral vessels, edema and intraretinal hemorrhages, with superiority to fluorescein angiography especially in the presence of retinal hemorrhages and retinal edema. OCTA with the help of the co-registered en face OCT images, can demonstrate laser scars, at the level of the choriocapillaris and can help in detecting disc edema. Statistical analysis of the incidence of the different pathological findings in CRVO, has revealed more severe affection of the deep capillary plexus than the superficial one. Conclusion: OCTA allows stratigraphic analysis of the retinal and choroidal vasculatures. It also allows performing quantitative flow analysis of the retinal vasculature providing an easily interpretable noninvasive objective tool for the management and monitoring the progression of CRVO. | ||||
| Keywords | ||||
| Central Retinal vein occlusion; Optical coherence tomography angiography; Fluorescein angiography | ||||
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