HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS
El-Noweihi, A., Elmelegy, N., Bakar, S., El-Nasser, S. (2019). HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS. EKB Journal Management System, 42(1), 19-29. doi: 10.21608/bfsa.2019.62260
Amira M. El-Noweihi; Nagla Taha Elmelegy; Sally M. Bakar; Shimaa El-Nasser. "HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS". EKB Journal Management System, 42, 1, 2019, 19-29. doi: 10.21608/bfsa.2019.62260
El-Noweihi, A., Elmelegy, N., Bakar, S., El-Nasser, S. (2019). 'HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS', EKB Journal Management System, 42(1), pp. 19-29. doi: 10.21608/bfsa.2019.62260
El-Noweihi, A., Elmelegy, N., Bakar, S., El-Nasser, S. HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS. EKB Journal Management System, 2019; 42(1): 19-29. doi: 10.21608/bfsa.2019.62260

HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS

Bulletin of Pharmaceutical Sciences Assiut University
Article 3, Volume 42, Issue 1, 2019, Page 19-29  XML PDF (985.3 K)
DOI: 10.21608/bfsa.2019.62260
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Authors
Amira M. El-Noweihi1; Nagla Taha Elmelegy1; Sally M. Bakar1; Shimaa El-Nasser* 2
1Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Egypt
2Department of Biochemistry, Faculty of Pharmacy, South Valley University, Egypt
Abstract
Aside from being a social stigma, obesity is frequently associated with insulin resistance, in turn linked to development of type II diabetes, hypertension, hyperlipidemia, and atherosclerosis – the so-called metabolic syndrome.This study investigated the biochemical changes in serum urea and creatinine levels in obese male rats treated with aqueous ginger extract. Forty age-matched adult male wister rats (90-110) gm were divided into four groups of ten rats each: Group I, Control group; Group II: Obese group. Group III: Low ginger dose (200 mg/kg body weight) treated obese group; Group IV: High ginger dose (400 mg/kg body weight) treated obese group.The obese group exhibited hyperglycemia accompanied with increasing in serum levels of Triglycerides (TG), Low Density Lipoprotein Cholesterol (LDL-C), Total Cholesterol (TC) levels. On the other hand, there was a significant reduction in High Density Lipoprotein Cholesterol (HDL-C) level. Ginger was effective in lowering all previous mentioned biochemical parameters and HDL-C level was increased significantly. Serum urea and creatinine levels showed a significant increase in obese rats. Otherwise, obese rats treated with ginger at either dose revealed a significant decrease as compared to obese group. These results indicated that the hypoglycemic and hypolipidemic effects of aqueous ginger extract (200, 400 mg/kg/day) could ameliorate obesity related kidney dysfunction.
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