ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION
Tamam, H., Abdel-Aleem, J., Abdelrahman, S., Abdelrahman, A., Yeo, Y. (2019). ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION. EKB Journal Management System, 42(1), 31-38. doi: 10.21608/bfsa.2019.62263
Hassan Tamam; Jelan A. Abdel-Aleem; Sayed I. Abdelrahman; Aly A. Abdelrahman; Yoon Yeo. "ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION". EKB Journal Management System, 42, 1, 2019, 31-38. doi: 10.21608/bfsa.2019.62263
Tamam, H., Abdel-Aleem, J., Abdelrahman, S., Abdelrahman, A., Yeo, Y. (2019). 'ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION', EKB Journal Management System, 42(1), pp. 31-38. doi: 10.21608/bfsa.2019.62263
Tamam, H., Abdel-Aleem, J., Abdelrahman, S., Abdelrahman, A., Yeo, Y. ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION. EKB Journal Management System, 2019; 42(1): 31-38. doi: 10.21608/bfsa.2019.62263

ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 42, Issue 1, 2019, Page 31-38  XML PDF (709.99 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2019.62263
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Authors
Hassan Tamam* 1; Jelan A. Abdel-Aleem2; Sayed I. Abdelrahman2; Aly A. Abdelrahman2; Yoon Yeo3
1Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
3Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA
Abstract
Liposomes are used for systemic delivery of chemotherapeutic drugs to reduce their nonspecific side effects. Liposomes can encapsulate hydrophilic and lipophilic drugs in the water compartment and the lipid membrane, respectively. However, typical drug loading capacity of liposomes by passive loading method is less than 1%. The low drug loading efficiency is problematic because it necessitates the use of a large amount of carrier materials that may cause undesirable biological effects. To increase drug loading in liposomes, weusedsupersaturated drug solutionswith gemcitabine (GEM) and doxorubicin (Dox) as examples. The prepared liposomes showed higher drug loading compared with passive loading, maintainedstabilityand provided sustained drug release for 48 hrs.
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