FORMULATION AND EVALUATION OF ORAL SUSTAINED RELEASE ETHYL CELLULOSE MICROPARTICLES INCORPORATED WITH FLURBIPROFEN | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 2, Volume 39, Issue 1, 2016, Page 27-41 PDF (537.74 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2016.62583 | ||||
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| Authors | ||||
| Ahmed A. H. Abdellatif1; Mohamed El Hamd* 2; Ramadan Ali2; Khaled I. Saleh1 | ||||
| 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt | ||||
| 2Department of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assuit, Egypt | ||||
| Abstract | ||||
| A great effort has been devoted to develop a method for delivering an efficient potent analgesic drug flurbiprofen (FLB) into more absorbed and small polymeric microparticles ethyl cellulose (EC), moreover to avoid the absorption at the acidic pH of the stomach. EC microparticles loaded with FLB were prepared by emulsion-solvent evaporation. A complete study for the encapsulation efficiency percent (EE%), the size and weight of the microparticles incorporated with FLB were studied and optimized. The release profiles of FLB from EC microparticles were measured in Sorensen phosphate buffer (0.1 M, pH 7.4). The results showed that EE% for all forms of microparticles was decreased as drug : polymer ratios decreased. The microparticles had a mean diameter of 30-80 µm as showed by scanning electron microscopy, confirming that the structure was in micro-size, moreover the release rate of FLB from microparticles was strikingly lower than that from drug itself. The results allow for the conclusion that the formulated microparticles serve as promising platform to improve the solubility, absorption and sustained release of FLB. | ||||
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