Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients
Abd El-Hafeez, H., Al-Alashkar, A., Mohamed, N., Zoheir, M. (2019). Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients. EKB Journal Management System, 77(5), 5681-5689. doi: 10.21608/ejhm.2019.62671
Hafez Ahmed Abd El-Hafeez; Ahmed Mohammed Al-Alashkar; Nagah Mohamed Abo Mohamed; Mohammed Ibrahim Khalil Zoheir. "Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients". EKB Journal Management System, 77, 5, 2019, 5681-5689. doi: 10.21608/ejhm.2019.62671
Abd El-Hafeez, H., Al-Alashkar, A., Mohamed, N., Zoheir, M. (2019). 'Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients', EKB Journal Management System, 77(5), pp. 5681-5689. doi: 10.21608/ejhm.2019.62671
Abd El-Hafeez, H., Al-Alashkar, A., Mohamed, N., Zoheir, M. Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients. EKB Journal Management System, 2019; 77(5): 5681-5689. doi: 10.21608/ejhm.2019.62671

Association between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients

The Egyptian Journal of Hospital Medicine
Article 21, Volume 77, Issue 5, October 2019, Page 5681-5689  XML PDF (452.51 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.62671
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Authors
Hafez Ahmed Abd El-Hafeez1; Ahmed Mohammed Al-Alashkar1; Nagah Mohamed Abo Mohamed2; Mohammed Ibrahim Khalil Zoheir email 1
1Department of Internal Medicine, Faculty of Medicine, Al-Azhar University
2Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University
Abstract
Background: End stage renal disease patients on regular hemodialysis patients have higher rate of mortality and morbidity compared to the general population. Objective: This study aimed to study the association between neutrophil-to-lymphocytic ratio and other inflammatory markers (IL-6, high sensitive CRP, PLR, etc) in hemodialysis patients. Patients and methods: This study was designed to assess inflammation in hemodialysis patients and study the association between high sensitive CRP (hs-CRP) and the other inflammatory markers in those patients. Initially, forty two patients with end stage renal disease (ESRD), on regular hemodialysis in dialysis unit, Internal Medicine Department, AL-Hussien Hospital, Faculty of Medicine, Al-Azhar University-Egypt. Results: We calculated the cut off point for IL-6 that best indicates the presence of inflammation in hemodialysis patients, we found that it was value more than 30 ng/l with sensitivity 96.6, specificity 69.2%, with AUC: 00.77 and P < 0.004. Moreover, we calculated the cutoff point for PLR that is consistent with presence of inflammation in hemodialysis patients, we found that it was more than 180.2 with sensitivity 82.2%, specificity 92.3% with AUC .087 and p value equals 0.0001. In addition to calculating the cut off point for NLR that best indicates the presence of inflammation, we found that it was ≥1.6 with sensitivity 93.1%, specificity 92.3%, with AUC: 0.92 and P < 0.001. Conclusion: We can assess cardiovascular condition of our hemodialysis patients along with their morbidity and mortality with measuring these inflammatory markers which are nonexpensive and has high sensitivity and specificity.
Keywords
Neutrophil to Lymphocyte Ratio; Hemodialysis patients; ESRD; CVD
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