An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep
Shalaby, H., Hassan, N., Nasr, S., Korany, T., Abu El Ezz, N., Abu zeina, H. (2020). An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep. EKB Journal Management System, 51(1), 93-103. doi: 10.21608/ejvs.2019.19195.1119
Hatem A. Shalaby; Noha M,F Hassan; Soad M. Nasr; Tarek Korany; Nadia mohamed Talaat Abu El Ezz; Hala A. Abu zeina. "An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep". EKB Journal Management System, 51, 1, 2020, 93-103. doi: 10.21608/ejvs.2019.19195.1119
Shalaby, H., Hassan, N., Nasr, S., Korany, T., Abu El Ezz, N., Abu zeina, H. (2020). 'An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep', EKB Journal Management System, 51(1), pp. 93-103. doi: 10.21608/ejvs.2019.19195.1119
Shalaby, H., Hassan, N., Nasr, S., Korany, T., Abu El Ezz, N., Abu zeina, H. An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep. EKB Journal Management System, 2020; 51(1): 93-103. doi: 10.21608/ejvs.2019.19195.1119

An Anthelmintic Assessment of Balanites aegyptiaca Fruits on Some Multiple Drug Resistant Gastrointestinal Helminthes Affecting Sheep

Egyptian Journal of Veterinary Sciences
Article 12, Volume 51, Issue 1, April 2020, Page 93-103  XML PDF (2.22 MB)
Document Type: Original Article
DOI: 10.21608/ejvs.2019.19195.1119
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Authors
Hatem A. Shalaby1; Noha M,F Hassan email orcid 1; Soad M. Nasrorcid 2; Tarek Korany1; Nadia mohamed Talaat Abu El Ezzorcid 3; Hala A. Abu zeinaorcid 4
1Department of Parasitology and Animal Diseases, National Research Centre, Giza, Egypt,
2Department of Parasitology and Animal Diseases, National Research Centre, 33 Bohouth Street, Dokki, Post Box 12622, Giza, Egypt.
3Depat. Parasitology, NRC,Cairo, Egypt
4Department of Parasitology and Animal Diseases, National Research Centre, Giza, Egypt
Abstract
The goal of this study is to evaluate the effect of Balanites aegyptiaca methanolic extract fruits as an alternative sustainable source of anthelmintic drugs, on adult gastrointestinal multiple drug resistant helminthes and clarify how B. aegyptiaca fruits directly affect helminthes. To fulfill this study, three hundred and fifty sheep reared in a private farm, in Giza Governorate, had been subjected to clinical investigation. Of them, fifty five severely affected sheep had been isolated relying on their clinical history of multiple anthelmintic resistances, to be slaughtered. The post mortem examination revealed that the animals had a mixed infection with Haemonchus contortus, Moniezia expansa and Fasciola gigantica. Light and scanning electron microscopic studies were undertaken to evaluate changes in body wall of these adult worms following 24 h exposure to methanolic extract of B. aegyptiaca fruits utilizing concentrations of 10, 50, 100, 200 and 400 µg/ml. The main target organ that was highly affected was the body wall, whose damage was observed by light and scanning electron microscopic studies. These alterations occurred in particular sequences in response to Balanites extract concentration, initiated with swelling that was even disrupted, resulting in sloughing off cuticle or tegument, and finally exposure and disruption of basal lamina. This damage would induce disturbance for many of the physiological processes associated with the body wall, especially nutrition and immunoprotection. This plant may offer an opportunity for a new natural anthelmintic and an alternative source for the control of such infectious disease in sheep.
Keywords
sheep; Haemonchus contortus; Moniezia expansa; Fasciola gigantica; Balanites aegyptiaca fruits
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