CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY
M., H., A., A., A., E., A., H., A., S. (2007). CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY. EKB Journal Management System, 31(2), 301-314. doi: 10.21608/ejom.2007.631
Hassanein M.; Abbas A.; El-Hawary A.; Hammad A.; Saad A.. "CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY". EKB Journal Management System, 31, 2, 2007, 301-314. doi: 10.21608/ejom.2007.631
M., H., A., A., A., E., A., H., A., S. (2007). 'CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY', EKB Journal Management System, 31(2), pp. 301-314. doi: 10.21608/ejom.2007.631
M., H., A., A., A., E., A., H., A., S. CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY. EKB Journal Management System, 2007; 31(2): 301-314. doi: 10.21608/ejom.2007.631

CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY

Egyptian Journal of Occupational Medicine
Article 7, Volume 31, Issue 2, July 2007, Page 301-314  XML PDF (862.19 K)
Document Type: Study paper
DOI: 10.21608/ejom.2007.631
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Authors
Hassanein M.1; Abbas A.1; El-Hawary A.1; Hammad A.2; Saad A.3
1Departments of Forensic Medicine and Clinical Toxicology, Community, Environmental and Occupational Medicine
2Faculty of Medicine - Zagazig University; Human Cytogentics,and Environmental and Occupational Medicine
3Environmental and Occupational Medicine , National Research Centre, Egypt
Abstract
Background: Certain chromium compounds are prominent metal carcinogens in both occupational and environmental settings. Objectives: The present study aimed to determine cytogenetic changes in the form of sister chromatid exchanges (SCEs) and predict chromium carcinogenicity in steel foundry workers; moreover, study the relationships between SCEs and tumor marker (CA 15-3) with the urinary chromium levels in the same group. Subjects and methods: The study included three groups; 20 apparently healthy male steel foundry workers, from different work sections, 20 apparently healthy male workers not exposed to chromium compounds, as a negative control group, and 10 lung cancer male patients from the National Cancer Institute, as a positive control group. All participants were interviewed using a pre-constructed questionnaire. Furthermore, they were subjected to urinary chromium level estimation,cytogentic study in the form of SCEs, and tumor marker (CA15-3) level measurement.Results: Steel workers had significantly higher levels of urinary chromium (5.5 ± 1.01 ٥g/L) compared to the other two groups (0.7 ± 0.19 and 0.8 ± 0.22 ٥g/L)
(P<0.001). Also, steel workers had significantly higher SCEs and CA15-3 levels compared to the negative controls (non-exposed workers) (P<0.001), but significantlyexperimenlower than those of the positive controls (lung cancer patients) (P<0.01). Moreover in the studied steel workers, there were significant positive correlations between urinary chromium levels and both SCEs and CA15-3 levels. Conclusion: It could be concluded that, unprotected occupational exposure to chromium in steel production industry can carry the risk of developing cytogenetic changes and cancer. These effects can be predicted by estimation of SCEs and tumor marker (CA 15-3) levels. Recommendations: Periodic medical examinations and biological monitoring of steel foundry workers, along with improving working conditions are ommended.
Keywords
Steel foundry workers; urinary chromium; sister chromatid exchanges; and tumor marker (CA15-3)
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