IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES
Mahrous, G., Shazly, G., Auda, S., Tawfeek, H. (2015). IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES. EKB Journal Management System, 38(1), 91-98. doi: 10.21608/bfsa.2015.63177
Gamal M. Mahrous; Gamal A. Shazly; Sayed H. Auda; Hesham M. Tawfeek. "IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES". EKB Journal Management System, 38, 1, 2015, 91-98. doi: 10.21608/bfsa.2015.63177
Mahrous, G., Shazly, G., Auda, S., Tawfeek, H. (2015). 'IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES', EKB Journal Management System, 38(1), pp. 91-98. doi: 10.21608/bfsa.2015.63177
Mahrous, G., Shazly, G., Auda, S., Tawfeek, H. IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES. EKB Journal Management System, 2015; 38(1): 91-98. doi: 10.21608/bfsa.2015.63177

IN-VITRO AND IN-VIVO EVALUATION OF SUSTAINED-RELEASE SUPPOSITORIES CONTAINING THEOPHYLLINE MICROSPHERES

Bulletin of Pharmaceutical Sciences Assiut University
Article 5, Volume 38, Issue 1, 2015, Page 91-98  XML PDF (438.49 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2015.63177
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Authors
Gamal M. Mahrous1; Gamal A. Shazly* 1, 2; Sayed H. Auda1, 3; Hesham M. Tawfeek2
1Department of Pharmaceutics, King Saud University, PO Box 2457, Riyadh 11451, Saudi Arabia
2Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University 71526, Assiut, Egypt
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy,Al-zhar University, Assiut, Egypt
Abstract
The sustained release microspheres of theophylline were formulated using non-solvent addition technique. The in-vitro dissolution of the drug from the fabricated microspheres that having size ranges of 300-600, 600-800 and 800-1000 µm was tested. The release of theophylline was extended over 8 hrs and it was found that the drug release decreased nonsignificantly as the particle size increased (p≥ 0.05). Incorporating theophylline-containing microspheres into suppository formulation using polyethylene glycol base resulted in a slight increase in dissolution rate, but still in a sustained release pattern over 8 hrs. In-vivo study of the prepared suppositories on beagle dogs revealed that the peak of theophylline serum concentration Cmax (mean±S.D) was 11.1+0.3 µg/mL. It was also found that AUC(0–24hrs) value averaged 154.7±20.3 µg-h/ml. The median peak time (Tmax) was 3.0 hrs and MRT was 13 hrs indicating a sustained effect.
 
 
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