FORMULATION AND EVALUATION OF A BUCCOADHESIVE CAPTOPRIL TABLETS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 3, Volume 32, Issue 1, June 2009, Page 45-64 PDF (370.07 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2009.63344 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mohammed H. El-Shabouri; Hamdy M. Abd El-Aleem; Osama A. Soliman; Marwa S. El-Dahhan | ||||
| Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt | ||||
| Abstract | ||||
| Buccoadhesive tablets of captopril were prepared by direct compression of the drug with different polymers; Carbopol 934 (CP 934), Eudragit RS 100 (EU RS 100), Chitosan (Ch), Hydroxpropyl methylcellulose (HPMC) and Polyvinylpyrrolidone K30 (PVP K30) either singly or in blends of different ratios. The tablets were evaluated for their weight variation, drug content uniformity, friability, hardness, swelling index, surface pH, in-vitro bioadhesive strength and release characteristics. The bioavailability and the pharmacokinetics parameters of captopril from two selected formulations (CP 934:HPMC 6:4 and Ch:HPMC 6:4) were evaluated. The in-vitro bioadhesive strength and release characteristics were found to be a function of the type of polymer and ratio of polymer blends. Swelling and bioadhesive characteristics were determined for both plain and medicated tablets. The high concentration of carbopol and chitosan containing formulations showed the greatest adhesive strength. The mean pharmacokinetic parameters of captopril after buccoadhesive tablet administration were: Cmax 506.9 ng/ml, Tmax 4 hr, AUC0-8 2359.5 ng.hr/ml for CP 934: HPMC (6:4), while Cmax 429.02 ng/ml, Tmax 2.67 hr, AUC0-8 1637.43 ng.hr/ml for Chitosan: HPMC (6:4). In comparison, in case of oral administration of control tablet the Cmax 591.28 ng/ml, Tmax 1.5 hr, AUC0-8 1869.29 ng.hr/ml. | ||||
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