5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.
M. Abdelazim, A., I. Ghaleb, K. (2015). 5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.. EKB Journal Management System, 11(1), 42-51. doi: 10.21608/blj.2015.63392
Aaser M. Abdelazim; Khaled I. Ghaleb. "5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.". EKB Journal Management System, 11, 1, 2015, 42-51. doi: 10.21608/blj.2015.63392
M. Abdelazim, A., I. Ghaleb, K. (2015). '5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.', EKB Journal Management System, 11(1), pp. 42-51. doi: 10.21608/blj.2015.63392
M. Abdelazim, A., I. Ghaleb, K. 5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.. EKB Journal Management System, 2015; 11(1): 42-51. doi: 10.21608/blj.2015.63392

5, 10-methylenetetrahydrofolate reductase C677T missense mutation is involved in recurrent pregnancy losses in Egyptian women.

Biochemistry Letters
Article 3, Volume 11, Issue 1, 2015, Page 42-51  XML PDF (390.19 K)
Document Type: Original Article
DOI: 10.21608/blj.2015.63392
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Authors
Aaser M. Abdelazim1; Khaled I. Ghaleb2
1Department of Biochemistry, faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
2Department of cancer biology, National cancer institute, Cairo University, Cairo, Egypt.
Abstract
Objectives: Thrombosis usually associated with many mutations, the condition which predisposed for recurrent pregnancy losses in women. In the present study we aimed to test the link between recurrent pregnancy losses and C677T missense mutation of 5, 10-methylenetetrahydrofolate reductase in Egyptian women. Methods: In the present study we tested the methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation, MTHFR activities in placental tissues and serum homocysteine level in Egyptian women with a history of recurrent pregnancy losses .The study included 150 subjects of a history of more than one recurrent pregnancy loss matched with 100 normal subjects with a history of normal delivery with no complications. Results: MTHFR C677T mutation was detected in (45.4%) of patients and in (4%) of control. Homozygous with mutant alleles were detected only among patients. The lowest placental MTHFR activities were detected among patients with heterozygous mutations, a significant increase in the plasma homocysteine is observed in all patients with MTHFR mutation compared with control. Conclusion: MTHFR C677T mutation is significantly involved in RPLs in Egyptian women. 
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