Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment
B. E, B., A.H., A., AT, K., M.A, K. (2015). Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment. EKB Journal Management System, 11(1), 80-88. doi: 10.21608/blj.2015.63398
Bayoumy B. E; Atta A.H.; Keshta. AT; Kifafy. M.A. "Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment". EKB Journal Management System, 11, 1, 2015, 80-88. doi: 10.21608/blj.2015.63398
B. E, B., A.H., A., AT, K., M.A, K. (2015). 'Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment', EKB Journal Management System, 11(1), pp. 80-88. doi: 10.21608/blj.2015.63398
B. E, B., A.H., A., AT, K., M.A, K. Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment. EKB Journal Management System, 2015; 11(1): 80-88. doi: 10.21608/blj.2015.63398

Interleukin 17 levels used as diagnostic marker for following up hepatitis C virus treatment

Biochemistry Letters
Article 7, Volume 11, Issue 1, 2015, Page 80-88  XML PDF (832.89 K)
Document Type: Original Article
DOI: 10.21608/blj.2015.63398
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Authors
Bayoumy B. E1; Atta A.H.2; Keshta. AT1; Kifafy. M.A1
1Biochemistry Department, Faculty of Science, Zagazig University.
2Immunology department, faculty of medicine, Zagazig University.
Abstract
 




 Background: Hepatitis C virus (HCV) causes significant morbidity and mortality worldwide. The infection induces up- regulation of cytokine and chemokine's commonly linked to the development of cellular and pro-inflammatory antiviral responses. The current standard in hepatitis C treatment consists of combination regimens of pegylated interferon-alpha plus ribavirin. Aim: This study was carried to follow up and monitoring the level of IL-17 in Hepatitis C infected patient before and after 120 days of treatment. Materials & Methods: Our study involved 120 HCV infected patients & 20 healthy persons; divided into three groups. Group I: IL-17 levels were measured in all subjects before and after 120 days of treatment. Also, Routine liver function tests were performed to all subjects included (aminotransferase (AST; alanine aminotransferase (ALT); Albumin; Total bilirubin; Direct Bilirubin, and alpha fetoprotein. 
Results: our results demonstrated that; the level of IL-17 was increased in hepatic infected patients than the healthy group and also increased after 120 days of treatment, there is significance increased in other parameters as AST , ALT, AFP, while significance decrease in the level of Albumin. AUC (area under curve) value represents the combined effects of both sensitivity and specificity of Il-17 before and after treatments, as the sensitivity and specificity of it was 100% and 100%; respectively before treatment, was 70% and 100%; respectively after treatment. Conclusion: IL-17 was a sensitive & specific marker in the following-up and monitoring HCV patients treated with interferon and ribavirin. 
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