Biological and phytochemical review on the genus Coccoloba (Polygonaceae) | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Article 5, Volume 3, Issue 2 - Serial Number 6, June 2019, Page 180-194 PDF (941.46 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/aps.2019.17343.1013 | ||||
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| Authors | ||||
Fatma Abdel Hakim1; Haidy A. Gad2; Rasha Ali Radwan3; Nahla Ayoub4; Mohamed El-Shazly  2
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| 1Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt | ||||
| 2Pharmacognosy Department, Faculty of Pharmacy, Ain-Shams University, Cairo Egypt | ||||
| 3Biochemistry Department, Faculty of Pharmacy, Sinai University, East Kantara Branch, New City, El Ismailia, 41611, Egypt | ||||
| 4Department of Pharmacology and Toxicology, Faculty of Medicine, Umm al-Qura University, Makkah, Saudi Arabia | ||||
| Abstract | ||||
| Polygonaceae is one of the largest medicinal plant families, vastly distributed worldwide, containing around 1,200 species from 48 genera. Most of the species are located in the northern temperate region, while the other species are allocated from the tropics to the arctic. The prime genera in Polygonaceae are Eriogonum which includes 240 species, Rumex with 200 species, Coccoloba with 120 species, Persicaria with 100 species, and Calligonum with 80 species. Coccoloba is one of the most interesting genera of the family Polygonaceae in terms of biological activities and secondary metabolites. Plants of this genus are used worldwide in traditional folk medicine. The review is a comprehensive literature survey on different Coccoloba species regarding their biological activities and their isolated phytochemicals. Different classes of secondary metabolites were isolated from this genus including flavonoids, phenolic acids, tannins, triterpenes, diterpenes, anthraquinones, isochromene, and volatile oils. Crude extracts and isolated compounds of various Coccoloba species displayed diversity in biological activities. Further investigations are required to explore new bioactive compounds and their pharmacological activities. | ||||
| Keywords | ||||
| Coccoloba; Polygonaceae; Genotoxic and mutagenic activities; anti-inflammatory activity; larvicidal activity; Cytotoxic activity | ||||
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