Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.
Mohamed, F., Youssef, D., El-Shal, A., Abdelsalam, A. (2019). Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.. EKB Journal Management System, 15(1), 186-195. doi: 10.21608/blj.2019.63835
Faten Z. Mohamed; Doaa M. Youssef; Amal S. El-Shal; Asmaa A. Abdelsalam. "Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.". EKB Journal Management System, 15, 1, 2019, 186-195. doi: 10.21608/blj.2019.63835
Mohamed, F., Youssef, D., El-Shal, A., Abdelsalam, A. (2019). 'Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.', EKB Journal Management System, 15(1), pp. 186-195. doi: 10.21608/blj.2019.63835
Mohamed, F., Youssef, D., El-Shal, A., Abdelsalam, A. Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.. EKB Journal Management System, 2019; 15(1): 186-195. doi: 10.21608/blj.2019.63835

Transforming growth factor-beta in nephrotic syndrome and its Correlation with Albuminemia and Hyperlipidemia.

Biochemistry Letters
Article 14, Volume 15, Issue 1, 2019, Page 186-195  XML PDF (332.92 K)
DOI: 10.21608/blj.2019.63835
View on SCiNiTO View on SCiNiTO
Authors
Faten Z. Mohamed1; Doaa M. Youssef2; Amal S. El-Shal3; Asmaa A. Abdelsalam1
1Chemistry Department, Faculty of Science, Zagazig University, Egypt.
2Pediatrics Department, Faculty of medicine, Zagazig University, Egypt.
3Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Zagazig University, Egypt.
Abstract
Background: Nephrotic syndrome (NS) is one of the most commonly encountered glomerular diseases in children and a major contributor to the workload of pediatric nephrologists. Nephrotic syndrome is a chronic disease that is well known for its long term serious complications. among these complications albuminemia and dyslipidemia. Many studies has related albuminemia and dyslipidemia to other complications of Nephrotic syndrome as retinopathy and cardiovascular disease of nephrotic syndrome. Objectives: The main objective of this study was planned to elucidate the potential diagnostic role of transforming growth factor-beta (TGF-ß) as a novel biomarkers and its correlation with albuminemia and dyslipidemia in nephrotic syndrome among Egyptian children.  Methods: Serum level of TGF-ß was measured using ELISA, serum level of lipid profile and urinary proteins were estimated.  Results: Our study revealed that serum level of TGF-ß was higher in nephrotic cases than controls and its serum level was significantly negative correlated with serum albumin while it showed a significant positive correlation with urinary protein  and lipid indices levels in children with nephrotic syndrome (r= -0.88, P < 0.001) , (r= 0.85,P< 0.001) and (r=  , P < 0.001) respectively. Conclusions: our data confirmed that TGF-ß can serve as a potential diagnostic biomarker in nephrotic syndrome. Furthermore, it can assist in management of nephrotic syndrome pathogenesis due to its correlation with dyslipidemia and albuminemia which are the main clinical features of nephrotic syndrome.
Keywords
TGF-ß; nephrotic syndrome; albuminemia; dyslipidemia
Statistics
Article View: 253
PDF Download: 255