Factor V Leiden, Prothrombin and Methylene-tetrahydrofolate reductase genes mutations are associated with recurrent pregnancy losses in Egyptian women | ||||
Biochemistry Letters | ||||
Article 7, Volume 10, Issue 1, 2014, Page 82-90 PDF (642.73 K) | ||||
DOI: 10.21608/blj.2014.63855 | ||||
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Authors | ||||
Khaled I. Ghaleb1; Aaser M. Abdelazim2; Haytham A. Ali2 | ||||
1Department of cancer biology, National cancer institute, Cairo University, Cairo, Egypt. | ||||
2Department of Biochemistry, Faculty of vet. Medicine, Zagazig University, 44511. Zagazig, Egypt | ||||
Abstract | ||||
Background: Pregnancies are usually associated with increase tendency to thrombosis; many cases are associated with inherited or acquired risks. Objective: The present study tested the mutations in Factor V Leiden (FVL) G1691A, prothrombin (PT) G20210A, methylene-tetrahydrofolate reductase (MTHFR) C677T genes, and their association with recurrent pregnancy losses in Egyptian women. Results: The study included 150 subjects of a history of one or more recurrent pregnancy losses matched with 100 normal subjects with a history of normal delivery with no complications. FVL G1691A mutation was detected in (38%) of patients and in (5%) of control. PT G20210A mutation was detected in (6%) of patients with no detection in control. MTHFR C677T mutation was detected in (45.4%) of patients and in (4%) of control. Homozygous with mutant alleles for the three studied mutations were detected only among patients not control group. Conclusion: There is a significant association between mutations of FVL, PT and MTHFR and recurrent pregnancy loss in Egyptian women. | ||||
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