Aqueous extract of Costus Specious ameliorates the toxic effect of lead acetate on transcriptional factors of erythropioesis

Shehata, Yousef M.; Dowidar, Mohamed F.; Ali, Haytham A.; Abdelazim, Aaser M.; Elmogy, Eman M.

doi:10.21608/blj.2014.63859

	Aqueous extract of Costus Specious ameliorates the toxic effect of lead acetate on transcriptional factors of erythropioesis
Biochemistry Letters
Article 10, Volume 10, Issue 1, 2014, Page 126-134 PDF (775.58 K)
DOI: 10.21608/blj.2014.63859
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Authors
Yousef M. Shehata¹; Mohamed F. Dowidar¹; Haytham A. Ali²; Aaser M. Abdelazim²; Eman M. Elmogy³
¹Professors of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University,44511, Zagazig, Egypt
²Lecturers of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University, 44511, Zagazig, Egypt
³3 Master of Biochemistry, Biochemistry Department, Faculty of Veterinary medicine, Zagazig University, 44511, Zagazig, Egypt
Abstract
*Background:* The increase use of medicinal plants during last 5 years encourages us to study the possible effects of Coustus Speciosus. *Objective:* In the present study, we tested the effect of Costus speciosus on the toxicity of Lead acetate. *Results:* The results showed an increase of EPO and high expression levels of GATA-1 and FOG-1 while there is a low expressional level of SCF in animals treated with Costus speciosus. *Conclusion:* Costus Specious has the ability to ameliorate the toxicity of lead acetate on erythropioesis.
Keywords
Erythropioesis; erythropoietin; FOG-1; GATA-1; SCF


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