Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients
Rafat, M., Berengy, M., Abd alsamie, H., Ramadan, S. (2019). Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 77(6), 5841-5846. doi: 10.21608/ejhm.2019.64084
Mohamed Nabil Rafat; Mahmoud Saad Berengy; Hesham Samir Abd alsamie; Sallam El-sayed Ramadan. "Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients". EKB Journal Management System, 77, 6, 2019, 5841-5846. doi: 10.21608/ejhm.2019.64084
Rafat, M., Berengy, M., Abd alsamie, H., Ramadan, S. (2019). 'Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients', EKB Journal Management System, 77(6), pp. 5841-5846. doi: 10.21608/ejhm.2019.64084
Rafat, M., Berengy, M., Abd alsamie, H., Ramadan, S. Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients. EKB Journal Management System, 2019; 77(6): 5841-5846. doi: 10.21608/ejhm.2019.64084

Evaluation Of The Relationship Between Neutrophil-Lymphocyte Ratio and Insulin Resistance In Newly Diagnosed Type 2 Diabetes Mellitus Patients

The Egyptian Journal of Hospital Medicine
Article 10, Volume 77, Issue 6, October 2019, Page 5841-5846  XML PDF (568.53 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.64084
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Authors
Mohamed Nabil Rafat1; Mahmoud Saad Berengy2; Hesham Samir Abd alsamie3; Sallam El-sayed Ramadan* 2
1Department of Internal Medicine; Faculty of Medicine, Al-Azhar University (Cairo)
2Department of Internal Medicine, Damietta Faculty of Medicine, AlAzhar University
3Department of Clinical Pathology; Damietta Faculty of Medicine, AlAzhar University
Abstract
Background: Newly diagnosed type 2 diabetes mellitus (DM) is associated with insulin resistance (IR). This insulin resistance is related to state of chronic inflammation and inflammatory marker such as neutrophil lymphocyte ratio, which can be used as a predictor inflammatory marker for insulin resistance. Objectives: The aim of this study was to evaluate the relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus in New Demitta Hospital patients. Patients and methods: This study is a prospective one that was carried out on thirty (30) populations and sixty (60) patients newly diagnosed type 2 diabetes mellitus attending to Outpatient Clinic and Inpatient Department of Internal Medicine at Al-Azhar University Hospital, Damietta. All were subjected to full history and clinical examination, laboratory tests include, HOMA IR, HbA1c, serum fasting insulin, CBC, Fasting blood sugar, post prandial glucose level, ALT, AST, serum albumin, bilirubin, GGT, creatinine, urea, uric acid, cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, high sensitive C-reactive proteins, ESR, BMI and urine analysis. Results: Our study showed that there was statistically significant increased neutrophil-lymphocyte ratio and serum triglycerides in group newly diagnosed type 2 diabetes mellitus with IR (BI) in comparison with newly diagnosed type 2 diabetes mellitus without IR group (BII) and controlled group (A).The study showed a significant positive correlation of NLR with HOMA-IR and showed the risk predictors of IR including NLR, TG and HbA1c. Conclusion: The results of this study showed that in newly diagnosed type 2 DM with IR having increased NLR which can be considered as early predictor for IR in those patients.
Keywords
Neutrophil-lymphocyte ratio (NLR); Insulin resistance (IR); Inflammation; Type 2 diabetes mellitus
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