IMIDAZOLE ALKALOIDS FROM THE INDOPACIFIC SPONGE PERICHARAX HETERORAPHIS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 9, Volume 30, Issue 2, December 2007, Page 149-157 PDF (196.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2007.64196 | ||||
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| Authors | ||||
| A. A. Ali1; H. A. Hassanean1; Ehab S. Elkhayat2; Ru AnGelie Edrada3; Rainer Ebel3; Peter Proksch3 | ||||
| 1Department of Pharamcocnosy, Faculty of Pharmacy, Assiut University, 71526 Assiut, Egypt | ||||
| 2Department of Pharamcocnosy, Faculty of Pharmacy, Al-Azhar University (Assiut branch , 71524 Assiut, Egypt) | ||||
| 3Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität, Universitätsstr 1, 40225 Düsseldorf, Germany | ||||
| Abstract | ||||
| Chemical investigation of the sponge Pericharax heteroraphis (Polejeff) collected in Indonesia, has led to the isolation of three imidazole alkaloids, preclathridine-A (1), leucettamine-B (2) and leucettamine-A (3). The structures of the isolated compounds were unambiguously established by 1D and 2D NMR and mass data. This is the first report of this class of compounds from the P. heteroraphis sponge. Investigation of the antimicrobial activities of the isolated compounds showed that leucettamin-A (3) was active against the gram-positive bacteria Staphylococcus aureus and the fungus Cladosporium herbarum, while other compounds were inactive. | ||||
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