DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., Amin, A. (2007). DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY. EKB Journal Management System, 30(2), 213-234. doi: 10.21608/bfsa.2007.64201
S. M. El-Moghazy Aly; D. E. Abdel Rahman; S. E. -S. Abbas; M. A. - A. Mohammed; A. H. Amin. "DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY". EKB Journal Management System, 30, 2, 2007, 213-234. doi: 10.21608/bfsa.2007.64201
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., Amin, A. (2007). 'DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY', EKB Journal Management System, 30(2), pp. 213-234. doi: 10.21608/bfsa.2007.64201
El-Moghazy Aly, S., Abdel Rahman, D., -S. Abbas, S., - A. Mohammed, M., Amin, A. DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY. EKB Journal Management System, 2007; 30(2): 213-234. doi: 10.21608/bfsa.2007.64201

DESIGN AND SYNTHESIS OF SOME SUBSTITUTED ACRIDINE DERIVATIVES OF ANTICIPATED ANTITUMOR ACTIVITY

Bulletin of Pharmaceutical Sciences Assiut University
Article 10, Volume 30, Issue 2, December 2007, Page 213-234  XML PDF (449.89 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2007.64201
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Authors
S. M. El-Moghazy Aly1; D. E. Abdel Rahman1; S. E. -S. Abbas1; M. A. - A. Mohammed1; A. H. Amin2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Beni Sueif University, Egypt
Abstract
Four series of new acridine derivatives of anticipated antitumor
activity have been designed and synthesized. The first series
belongs to 4-substituted phenylhydrazinocarbonylmethyl 9-oxo-
9,10-dihydroacridine-4-carboxylate 10a-h. The second series consists of phenylhydrazinocarbonylmethyl 9-(4-substituted
phenyl)aminoacridine-4-carboxylate 12a-k, while the third series
comprises 4-substituted phenylcarbamoylmethyl 9-(4-substituted
phenyl)aminoacridine-4-carboxylate 15a-k. The fourth one belongs
to phenylcarbamoylmethyl 9-(4-substituted phenyl)aminoacridine-
4- carboxylate 17a-j. The chemical structure of synthesized
compounds was elucidated by spectral data and elemental analysis.
Seventeen selected compounds (10a, 10g, 10h, 12a, 12d, 12g, 12h,
12k, 15a, 15c, 15g, 15h, 15k, 17a, 17f, 17g and 17j) were tested
against breast cancer cell line (MCF7) and eight compounds (12g,
12h, 12k, 15g, 15h, 17f, 17g, 17j) were found to exhibit significant
antitumor activity
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