SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES
A. Khalifa, M., F. Ismail, M., Noaman, E. (2008). SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES. EKB Journal Management System, 31(1), 69-80. doi: 10.21608/bfsa.2008.64215
Maha M. A. Khalifa; Magda M. F. Ismail; Eman Noaman. "SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES". EKB Journal Management System, 31, 1, 2008, 69-80. doi: 10.21608/bfsa.2008.64215
A. Khalifa, M., F. Ismail, M., Noaman, E. (2008). 'SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES', EKB Journal Management System, 31(1), pp. 69-80. doi: 10.21608/bfsa.2008.64215
A. Khalifa, M., F. Ismail, M., Noaman, E. SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES. EKB Journal Management System, 2008; 31(1): 69-80. doi: 10.21608/bfsa.2008.64215

SYNTHESIS AND IN-VITRO CYTOTOXIC ACTIVITY OF NOVEL BENZO[b]PHENAZINE-6,11-DIONE AND 1,4- NAPHTHOQUINONE DERIVATIVES

Bulletin of Pharmaceutical Sciences Assiut University
Article 4, Volume 31, Issue 1, June 2008, Page 69-80  XML PDF (196.59 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2008.64215
View on SCiNiTO View on SCiNiTO
Authors
Maha M. A. Khalifa* 1; Magda M. F. Ismail1; Eman Noaman2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr City, Cairo, Egypt
2Department of Radiation Biology, Natural Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt
Abstract
5,12-Dihydrobenzophenazine-6,11-diones,2-Arylamino-3-
chloro-1,4-naphthoquinones and 6,11-dihydrobenzo[b]phenazine-
6,11-diones, were synthesized from 2,3-dichloro-1,4-naphthoquinone
and arylamines/phenylenediamines. Studying the
cytotoxicity using EAC and human cell lines revealed that 5,12-
dihydrobenzo[b]phenazine-6,11-dione (3) and 3-chloro-2-(2-
pyridylamino)-1,4-naphthoquinone (10) showed selective
cytotoxicity against the human lung carcinoma cell line (H460)
superior to doxorubicin. Compound 3 (16.25 uM) was 1.3 times
higher than that of doxorubicin. However, IC50 value of compound
10 was 9.90 uM which was 2 times higher than that (20.10 uM) of
doxorubicin. These compounds were inactive against liver
carcinoma (HEPG2), brain tumor (U251), cervix carcinoma
(HELA) and breast carcinoma (MCF7) cell lines.
Statistics
Article View: 116
PDF Download: 226