INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS
Mohamed, F., Mussien, Y., Basiony, E. (2010). INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS. EKB Journal Management System, 7(1), 1-21. doi: 10.21608/blj.2010.64239
Faten Z. Mohamed; Yousri M. Mussien; Eman F. Basiony. "INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS". EKB Journal Management System, 7, 1, 2010, 1-21. doi: 10.21608/blj.2010.64239
Mohamed, F., Mussien, Y., Basiony, E. (2010). 'INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS', EKB Journal Management System, 7(1), pp. 1-21. doi: 10.21608/blj.2010.64239
Mohamed, F., Mussien, Y., Basiony, E. INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS. EKB Journal Management System, 2010; 7(1): 1-21. doi: 10.21608/blj.2010.64239

INTERLEUKIN-4 (IL-4) AND INTERLEUKIN-4 RECEPTOR ALPHA CHAIN (IL-4Rα) GENE POLYMORPHISMS IN EGYPTIAN RHEUMATIC ARTHRITIS PATIENTS

Biochemistry Letters
Article 1, Volume 7, Issue 1, 2011, Page 1-21  XML PDF (2.55 MB)
Document Type: Original Article
DOI: 10.21608/blj.2010.64239
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Authors
Faten Z. Mohamed1; Yousri M. Mussien2; Eman F. Basiony3
1Biochemistry Division, Dept. of Chemistry, Faculty of Science, Zagazig University
2Faculty of Medicine, Zagazig University, Egypt
3Faculty of Medicine, Zagazig University, Egypt.
Abstract
Rheumatoid arthritis (RA) is considered a Th1-driven disease. Interleukin 4 (IL-4) binds to its receptor, promoting Th2 differentiation and limiting Th1 responses, but its role in the pathogenesis of RA is conflicting. Objective: to evaluate the occurrence of variants of interleukin-4 (IL-4) and Interleukin-4 Receptor Alpha chain (IL-4 RA) gene in patients with rheumatoid arthritis and their possible contribution to disease severity. Methods: We analyzed 2 polymorphisms of the IL4 gene and 2 polymorphisms of IL-4 RA in patients with RA and in a control population, as well as measuring serum RF as a disease severity parameter. Results: The IL-4 –590 TT genotype (P<0.001) and The IL4 –590T allele (OR 2.84, 95% CI 1.0-8.77, p=0.03) were significantly more frequent in patients with RA than in controls, this is similar for IL-4 VNTR RP1⁄RP1 genotype (P<0.001) and IL-4 RP1 allele (OR 2.91 CI 0.92-10.23, P=0.04). Higher frequency of IL-4 RA I50V genotypes (P= 0.02) in RA patients compared with controls were also found. Nevertheless, the more severe form of RA is observed in patients carrying the IL-4 -590 T allele as compared with homozygous patients. The IL-4RA Q576 allele and IL-4RA V50 allele were significantly associated with the sever form of RA. Conclusion: The IL-4 -590 C/T, IL-4 VNTR in intron-3 and IL-4Rα I50V polymorphism were associated with RA susceptibility in Egyptian population. IL-4Rα I50V and IL-4Rα Q576R polymorphisms may be may be a genetic risk factor for RA severity.
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