IMMUNOTOXIC ACTION OF POSTORAL ADMINISTRATION OF CARBON TETRACHLORIDE IN MALE ALBINO RAT | ||||
| Biochemistry Letters | ||||
| Article 2, Volume 7, Issue 1, 2011, Page 23-43 PDF (300.02 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/blj.2010.64240 | ||||
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| Authors | ||||
| Nagi A. Ibrahim; Al Ahmady S Alzahaby; Amr A. Shalaby; Eman S. El-Bahaie | ||||
| Zoology Department, Faculty of Science, Zagazig University | ||||
| Abstract | ||||
| Carbon tetrachloride (CCl4) was administered (p.o.) every other day for one month to male Sprague Dawely rats. At the first day after the treatment period, leucocytes (WBCs), and lymphocytes (LYM) numbers, and serum IgM level were significantly higher than those of the control values. At day 15 after CCl4 treatment period WBCs and LYM numbers were below the control levels, whereas, IgM was still above the control level, but lower than the value recorded at day one after CCl4 treatment period. The same dose level and treatment period of CCl4 induced significant increases in serum IL-4 and IL-6 levels that were lasted for 15 days post the administration period. Late administration (i.p.) of DMSO (0.5 ml/100 g b.wt.) at 30 minutes post CCl4 treatment period selectively prevented changes of WBCs and LYM.Tthese results indicate that the toxic effect of CCl4 under the present experimental conditions, could induce changes in both cellular and humoral immune response of rats and these changes could be selectively reversed with time and late administration of DMSO. | ||||
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