RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS
Hussein, Y., Nassar, S., El Shaer, N. (2012). RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS. EKB Journal Management System, 8(1), 139-164. doi: 10.21608/blj.2012.64274
Yousri M. Hussein; Samir Ab. Nassar; Nahla H. El Shaer. "RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS". EKB Journal Management System, 8, 1, 2012, 139-164. doi: 10.21608/blj.2012.64274
Hussein, Y., Nassar, S., El Shaer, N. (2012). 'RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS', EKB Journal Management System, 8(1), pp. 139-164. doi: 10.21608/blj.2012.64274
Hussein, Y., Nassar, S., El Shaer, N. RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS. EKB Journal Management System, 2012; 8(1): 139-164. doi: 10.21608/blj.2012.64274

RELATIONSHIP BETWEEN THE TUMOR NECROSIS FACTOR-Α AND ITS RECEPTOR GENE POLYMORPHISM AND TNF-Α PLASMA LEVELS IN EGYPTIAN RHEUMATOID ARTHRITIS PATIENTS

Biochemistry Letters
Article 11, Volume 8, Issue 1, 2012, Page 139-164  XML PDF (652.41 K)
DOI: 10.21608/blj.2012.64274
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Authors
Yousri M. Hussein1; Samir Ab. Nassar2; Nahla H. El Shaer2
1Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt and Head of Medical Laboratories Department, Faculty of Applied Medical Sciences, Taif University, Taif, KSA .
2Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
Abstract
Rheumatoid arthritis (RA) it is a model of multigenic
inflammatory disorder in which tumor necrosis factor-α (TNF-α)
plays an important role. Genetic factors may be implicated in the
susceptibility to disease initiation .Objective: The aim of this study is
to elucidate putative association between the −308 G/A
polymorphism in the promoter region of the TNF-α gene and
196M/R polymorphism of TNFRII genes and susceptibility to
disease onset of RA. Methods: A total of 160 RA patients and a
control group of 40 healthy subjects were available for the study. All
patients fulfilled the American College of Rheumatology revised
criteria for RA, Single-nucleotide polymorphisms (SNPs) at position
−308 of TNF-α and 196 of TNFRII genes were determined using
restriction fragment length polymorphism–polymerase chain
reaction (PCR–RFLP). The A allele of the −308 promoter
polymorphism was more prevalent among the patients. 308GA
genotype of TNF-α is associated with a significantly higher serum
TNF-α level. TNFRII 196R allele more prevalent among the
patients .Our findings suggest that the A allele of TNF-α and
TNFRII 196M/R polymorphism are associated with RA
susceptibility.
Keywords
Rheumatoid arthritis (RA); TNF-α; TNFRII; Gene polymorphism
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